Evaluation of in-vitro antibiotic susceptibility of different
morphological forms of Borrelia burgdorferi
morphological forms of Borrelia burgdorferi
Original Research
Authors: Sapi E, Kaur N, Anyanwu S, Luecke DF, Datar A, Patel S, Rossi M,
Stricker RB
Published Date May 2011 , Volume 2011:4 Pages 97 - 113 DOI
10.2147/IDR.
Results: Doxycycline reduced spirochetal structures ~90% but increased the
number of round body forms about twofold. Amoxicillin reduced spirochetal
forms by ~85%–90% and round body forms by ~68%, while treatment with
metronidazole led to reduction of spirochetal structures by ~90% and round body
forms by ~80%.
Tigecycline and tinidazole treatment reduced both spirochetal and round
body forms by ~80%–90%. When quantitative effects on biofilm-like colonies
were evaluated, the five antibiotics reduced formation of these colonies by
only 30%–55%. In terms of qualitative effects, only tinidazole reduced
viable organisms by ~90%.
Following treatment with the other antibiotics, viable organisms were
detected in 70%–85% of the biofilm-like colonies.
Conclusion: Antibiotics have varying effects on the different
morphological forms of B. burgdorferi. Persistence of viable organisms in round body
forms and biofilm-like colonies may explain treatment failure and persistent
symptoms following antibiotic therapy of Lyme disease.
Read full article here _http://www.dovepres
On the resulting page, click on the "Download Article" button to see full 17-page article.number of round body forms about twofold. Amoxicillin reduced spirochetal
forms by ~85%–90% and round body forms by ~68%, while treatment with
metronidazole led to reduction of spirochetal structures by ~90% and round body
forms by ~80%.
Tigecycline and tinidazole treatment reduced both spirochetal and round
body forms by ~80%–90%. When quantitative effects on biofilm-like colonies
were evaluated, the five antibiotics reduced formation of these colonies by
only 30%–55%. In terms of qualitative effects, only tinidazole reduced
viable organisms by ~90%.
Following treatment with the other antibiotics, viable organisms were
detected in 70%–85% of the biofilm-like colonies.
Conclusion: Antibiotics have varying effects on the different
morphological forms of B. burgdorferi. Persistence of viable organisms in round body
forms and biofilm-like colonies may explain treatment failure and persistent
symptoms following antibiotic therapy of Lyme disease.
Read full article here _http://www.dovepres
This is important research, thanks for sharing it.
ReplyDeleteI wish they had included Omnicef (a Cephalosporin) the study, perhaps it works similarly to Amoxicillin, which is a penicillin derivative. Cephalosporins are bactericidal and have the same mode of action as other beta-lactam antibiotics such as penicillins.
I'm really surprised there is no Cephalosporin (Rocephin anyone?) in the mix too. I was explaining to somebody recently that in vitro studies to in vivo realities is like Seal Team VI in Bin Laden's bedroom to the 10 years it took to find him. Maybe not a perfect analogy, or a cheerful one, but perhaps useful. I saw leaps of improvement on Tindemax, after some severe herxing with every dose, for about two months. Then the herxes slowly improved. Still working with it as part of my regime, with rocephin, switching back to zithromax eventually. Real improvements over a year of this. Good luck to all!
ReplyDelete