Monday, June 8, 2020

Genetic insights into the etiology of Parkinson’s disease

Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease


Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson's disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson's disease.....

For the rest of the article:

Doctors treat Parkinson’s with a novel brain cell transplant - STAT

Bob Cowart
Phone: 510-540-6667
Twitter: @bobcowart

Thursday, April 30, 2020

A Clinical Diagnostic System for Late-Stage Neuro Lyme Borreliosis

A Clinical Diagnostic System for Late-Stage Neuropsychiatric Lyme Borreliosis Based upon an Analysis of 100 Patients

A study by the respected researcher Robert Bransfield and three others. 

Healthcare | Free Full-Text |

Thursday, April 23, 2020

The Sounds of Science

Maybe you've seen this before but it applies more with each passing day...

Thursday, February 20, 2020

Mold, Air, Water, Sewage testing company

I've been looking for a company who can test air quality inside and outside of my house. I have wondered foe years whether my house's inside air was polluted, because in the AM when I awake, I often feel poisoned. I've looked into oxygen deprivation (which would cause CO2 poisoning) and mold, so far. I used Real Time labs for mold and micotoxin testing. I've treated my house and cars for micotoxins with chlorine dixoide gas. I still don't think I have found the culprit, but I suspect it has to do with gut dysbiosis more than with the external environment, though both may play a part. 

In any case, the testing that these folks do might be among my next areas of inquiry. 


Why Test for Sewage Contamination?

Exposure to sewage contamination increases the risk of contracting diseases of the digestive system and other related illnesses. Potential disease causing organisms in sewage contamination include E. coli (some strains), Salmonella, and Shigella.

Sewage contamination can come from flooding events, failing septic systems, wastewater treatment plants, sewer overflows, vessel sewer discharge, runoff from surfaces, livestock, pets, wildlife, and humans. 

The following bacteria are used as indicators of sewage contamination.

  • E. coli
  • Total coliforms
  • Fecal coliforms
  • Enterococci
  • Fecal Streptococcus.

These bacteria are not a health threat themselves but their presence is used as an indication of other potentially harmful bacteria.

Learn More...

General Bacteria Testing

Bacteria Testing

We perform various bacterial analytical tests at Mold & Bacteria Consulting Laboratories (MBL). We can test air samples (taken by an RCS sampler or an Anderson sampler), surface samples (taken by culture-swabs), and water samples, as well as many other types of samples. If you have a question regarding a particular test (including those not listed here), please ...

Continue Reading Online...

MBL Among The CDC ELITE Certified Labs in Legionella Testing

Mold & Bacteria Consulting Laboratories (MBL)  has certification in the analysis of Legionella bacteria by the prestigious Environmental Legionella Isolation Techniques Evaluation (ELITE) program of the US Centers for Diseases Control and Prevention (CDC). MBL is one of the only 3 Canadian independent laboratories having this industry-leading certification. MBL is also accredited by the Canadian Association For Laboratory Accreditation (CALA) ...

Continue Reading Online...

Online Mold Inspection, Identification and Control Course

Our online mold training course is designed for people with busy schedules. The course is available 24/7 and can be taken in office or at home at any time of the day. Click Online Mold Training Course for more details.

Happy to help.

If you have any questions regarding mold or bacteria laboratory testing, please contact us at 905-290-9101 or send an email to

Copyright © 2020 Mold & Bacteria Consulting Laboratories, All rights reserved. 
You are receiving this email because you opted in at our website or Facebook page 

Our mailing address is: 

Want to change how you receive these emails?
You can update your preferences or unsubscribe from this list 

Saturday, January 25, 2020

Stomach bacteria may slow - and even reverse - Parkinson's disease

Stomach bacteria may slow - and even reverse - Parkinson's disease

The study is published in Cell Reports.

Study Finds
Sat, 18 Jan 2020 00:01 UTC

© tutul_1410/

Parkinson's disease, a progressive nervous system disorder that greatly affects movement, can have a detrimental impact on one's quality of life. While there are medications available that help control its symptoms, there is no known cure for the disease. However, researchers from the Universities of Edinburgh and Dundee in Scotland recently identified a potential game changer in the fight against Parkinson's. A common probiotic, or "good" bacteria, found in our stomachs that helps maintain digestive health appears to be able to slow, and even reverse, the accumulation of a protein known to be associated with Parkinson's. 

The groundwork for these findings were put in place by prior research that had identified a connection between brain function and gut bacteria. Now, using a group of roundworms, this study has discovered that the probiotic called Bacillus subtilis is capable of stopping the formation of toxic clumps in the brain that impede the flow of dopamine. Dopamine, besides its other uses, is integral to coordinating movement. 

Within the brains of Parkinson's patients, the protein known as alpha-synuclein builds up, forming these aforementioned toxic clumps. These clumps then cause the death of nerve cells that should be producing dopamine. It's the loss of these very cells that cause the trademark symptoms of Parkinson's, such as shaking or overall slowness of movement. 

The research team used a genetically altered group of roundworms capable of producing the human version of clump-forming alpha-synuclein. These worms were fed a variety of different over-the-counter probiotics, in an effort to see if any of them influenced subsequent clump formation. 

The results of the experiment revealed that Bacillus subtilis had a robust protective effect that prevented the buildup of the alpha-synuclein protein. The probiotic even was able to do away with some pre-existing clumps that had already formed within the worms. After being given Bacillus subtilis, the worms movements immediately improved. 

"The results provide an opportunity to investigate how changing the bacteria that make up our gut microbiome affects Parkinson's. The next steps are to confirm these results in mice, followed by fast-tracked clinical trials since the probiotic we tested is already commercially available," says Lead researcher Dr. Maria Doitsidou, of the Centre for Discovery Brain Sciences at the University of Edinburgh, in a release. 

This piece of research is just the latest in a string of studies over the past few years indicating that the gut microbiome residing in each one our stomachs plays a critical role in brain function. 

"Parkinson's is the fastest growing neurological condition in the world. Currently there is no treatment that can slow, reverse or protect someone from its progression but by funding projects like this, we're bringing forward the day when there will be," comments Dr Beckie Port, Research Manager at Parkinson's UK. "Changes in the microorganisms in the gut are believed to play a role in the initiation of Parkinson's in some cases and are linked to certain symptoms, that's why there is ongoing research into gut health and probiotics. 

"The results from this study are exciting as they show a link between bacteria in the gut and the protein at the heart of Parkinson's, alpha synuclein. Studies that identify bacteria that are beneficial in Parkinson's have the potential to not only improve symptoms but could even protect people from developing the condition in the first place," she concludes. 

The study is published in Cell Reports.

Comment: See also:

Thursday, January 16, 2020

Commentary: Lyme disease led to my daughter’s death. Join the fight against tick-borne disease | CalMatters

Bad news, good news. 

By Jody Hudson, Special to CalMatters

My cause is personal, and my goal will not be deterred as I, and those joining with me, work to see that no other person suffers the way my daughter did.

A small tick bit her. That eventually led to her death. In 21st Century America, this should not have happened.

Alex Hudson's story exposes a medical system that remains unprepared to deal with debilitating illnesses that tick bites bring, including Lyme disease. 

In 2018, at age 22, Alex lost her battle with Lyme disease and the resulting Mast Cell Activation Syndrome, which caused her body to have an allergic-like reaction to almost anything she ate or drank.

Two-hundred children a day are diagnosed with Lyme disease. The U.S. Centers for

Disease Control and Prevention reports that cases of tick borne diseases had more than doubled from 2004 to 2016, from 22,000 to 48,000. 

Lyme disease accounted for 82% of all tick-borne diseases.

But you would never know when it comes to on-the-ground medical care. Alex spent a decade being shuttled….


--Bob Cowart