Sunday, February 26, 2017

New Tests for B. miyamotoi & other pathogens in New York

This could be a HUGE step forward in Lyme diagnosis and treatment!

-Bob
 2017 Mar;8(3):407-411. doi: 10.1016/j.ttbdis.2017.01.004. Epub 2017 Jan 16.

Detection of Borrelia miyamotoi and other tick-borne pathogens in human clinical specimens and Ixodes scapularis ticks in New York State, 2012-2015.

Author information

  • 1Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY 12208, United States. Electronic address: danielle.wroblewski@health.ny.gov.
  • 2Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY 12208, United States.
  • 3Vector Ecology Laboratory, Bureau of Communicable Disease Control, New York State Department of Health, Empire State Plaza C456-C467B, Albany, NY 12237, United States.

Abstract

Borrelia miyamotoi (Bm) is a recently emerging bacterial agent transmitted by several species of ixodid ticks. Diagnosis of Bm infection can be challenging, as the organism is not easily cultivable. 
We have developed and validated a multiplex real-time PCR to simultaneously identify Bm infection and the agents causing human granulocytic anaplasmosis and human monocytic ehrlichiosis, Anaplasma phagocytophilum and Ehrlichia chaffeensis, respectively. 
The assay is 100% specific; highly sensitive, detecting 11 gene copies of Bm DNA in both whole blood and cerebral spinal fluid; and provides rapid results in less than two hours. 
A retrospective study of 796 clinical specimens collected between the years 2012 and 2014 and a prospective study of 366 clinical specimens were performed utilizing this novel assay to evaluate the frequency of Bm infection in New York State (NYS). 
Eight clinical specimens (1%) were found to be positive for Bm, 216 were positive for A. phagocytophilum, and 10 were positive for E. chaffeensis. 
Additionally, we tested 411 I. scapularis ticks collected in NYS during 2013 and 2014 in a separate multiplex real-time PCR to determine the prevalence of Bm, A. phagocytophilum, Borrelia burgdorferi s.s., and Borrelia species. 
Our results indicated rates of 1.5%, 27%, 19.7%, and 8.8% respectively. The ability to monitor both the frequency and geographic distribution of Bm cases and the prevalence and geographic distribution of Bm in ticks will help create a better understanding of this emerging tick-borne pathogen.
Published by Elsevier GmbH.

KEYWORDS: 

Borrelia miyamotoi; Ixodes scapularis; Multiplex; Real-time PCR; Tick-borne disease
PMID:
 
28131594
 
DOI:
 
10.1016/j.ttbdis.2017.01.004
[PubMed - in process]
Link here

Tuesday, February 21, 2017

Targeting Gut Bacteria May Be The Key To Preventing Alzheimer's |

The Huffington Post


I see more and more articles about diseases, including Parkinson's, having a relationship to diet. Or more specifically, having a relationship with the gut microbiome. Here is yet another one. 

Bob

Sunday, January 29, 2017

Babesia Screening in the U.S. Blood Supply

SUMMARY AND COMMENT

Babesia Screening in the U.S. Blood Supply

Sonia Nagy Chimienti, MD Reviewing Moritz ED et al., N Engl J Med 2016 Dec 8; 375:2236

An investigational screening protocol used in high-risk regions appears effective in eliminating transfusion-associated babesiosis.


http://www.jwatch.org/na42948/2017/01/25/babesia-screening-us-blood-supply?query=etoc_jwid&jwd=000013533191&jspc=

Thursday, January 19, 2017

Michael Specter article from New Yorker



Here is a New Yorker magazine article written by Michael Specter, who has written a number of scientifically oriented articles for the lay audience, including this one about Lyme disease. This article focuses on whether gene editing technologies might be used to tackle the problem of Lyme disease.

Wednesday, January 18, 2017

Lyme disease in Pennsylvania

I grew up in Pennsylvania and believe it was there that I was first infected with Lyme, back in the summer of 1970. I was almost constantly in the woods because I had a summer job as a land surveyor's assistant. 

Pennsylvania Lyme disease: An interview with Dr Amesh Adalja


Senior Associate at the UPMC Center for Health Security, Amesh Adalja, MD 


Monday, January 16, 2017

A new book on Lyme. "Lyme Madness"

Statement by the author:

I'd like to let everyone know that I have recently published my book LYME MADNESS. It was named the #1 NEW RELEASE in Immune System health on Amazon. 

Lyme Madness chronicles my adult son's illness and all that we've learned along the way in this mad, mad world of Lyme, including trying to make sense of the ugly and corrupt medical politics. It is also a platform for the stories of many -- for those who have been forced to suffer in silence for years, even decades. 

                         

LORI DENNIS, M.A.

Gut microbes promote motor deficits in a mouse model of Parkinson's disease

Yet another article about the connection between the gut and Parkinson's disease. This is a study of mice who were genetically predisposed to Parkinson's disease and the effective antibiotics that seems to be protective against developing Parkinson's symptoms.

https://www.eurekalert.org/pub_releases/2016-12/cp-gmp112316.php

Tuesday, January 3, 2017

New Gut Discoveries (or old ones rediscovered)

Gut Decision: Scientists Identify New Organ in Humans

A mighty membrane that twists and turns through the gut is starting the new year with a new classification: the structure, called the mesentery, has been upgraded to an organ.

Scientists have known about the structure, which connects a person's small and large intestines to the abdominal wall and anchors them in place, according to the Mayo Clinic. However, until now, it was thought of as a number of distinct membranes by most scientists. Interestingly, in one of its earliest descriptions, none other than Leonardo da Vinci identified the membranes as a single structure, according to a recent review.

In the review, lead author Dr. Calvin Coffey, a professor of surgery at the University of Limerick's Graduate Entry Medical School in Ireland, and colleagues looked at past studies and literature on the mesentery. Coffey noted that throughout the 20th century, anatomy books have described the mesentery as a series of fragmented membranes; in other words, different mesenteries were associated with different parts of the intestines. 

Saturday, December 17, 2016

Cures Act passes!

The Lyme bill (Cures Act) passed through the House (344-77 vote), passed thru the Senate (94-5 vote), and on 12/13/16 the bill was signed by President Obama.  


To keep up with Lyme related legislation you can visit:


or 


or


or this Lyme Legislation website: