Monday, April 23, 2018

A clue on the connection between the microbiome and autoimmune disease

Lab Chat: How migrating gut bacteria might do damage

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SMALL INTESTINES STUDDED WITH E. GALLINARUM BACTERIA. (MANFREDO VIEIRA ET AL., SCIENCE 2018)

Scientists have discovered a particular microbe that can venture out of the gut and set up shop in other organs, where it seems to trigger an autoimmune response that's similar to what's seen in patients with lupus. The finding gives researchers new clues about the potential link between the microbiome and autoimmune disease. Here's what Dr. Martin Kriegel of Yale told me about the work, published in Science.

What did you discover about a potential link between the microbiome and lupus?

Studies have suggested autoimmune disease might have a microbial trigger. We gave mice that modeled autoimmune disease broad spectrum antibiotics to manipulate the microbes in the gut. We almost completely prevented mortality. But a big hurdle is figuring out which bacteria are behind the link, and how. So we tracked the bacteria with fluorescent tags.

What did you see?

We saw that E. Gallinarum bacteria somehow crossed the barrier of the gut and impacted immune cells. The bacteria tipped the balance from being prone to developing autoimmune disease to actually developing it. When we went to human liver tissue, we also found these microbes. We think it drives important autoimmune pathways.

Journal article:

Translocation of a gut pathobiont drives autoimmunity in mice and humans

Thursday, April 19, 2018

The Lyme Controversy & The Psychiatric/Cognitive Effects From Tickborne Infections

Here's a presentation by a psychiatrist who is very well versed in Lyme, about the weird brain symptoms that Lyme and coinfections in the nervous system can cause. 

-Bob

Saturday, April 14, 2018

Fwd: Putting Lyme on the national stage

Excellent book. Please help promote it. I heard Mary Beth speak about the book and her research while writing it. We need to spread the word about Lyme and the inequities foisted upon us as Lyme patients. Please explore the links in this email and forward this to friends and family, to doctors, legislators, etc.

Bob


Putting Lyme on the national stage
Here's how you can help
The more buzz created about this book, the more likely it will garner national media attention.

And that can help bring about substantial change. Topics that don't get talked about on the public stage are too easily ignored by policy makers. READ MORE.

Wednesday, April 4, 2018

Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease

This is an important study. 

-Bob


Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease
Version 1 : Received: 7 March 2018 / Approved: 8 March 2018 / Online: 8 March 2018 (07:08:02 CET) 
 
How to cite: Middelveen, M.J.; Sapi, E.; Burke, J.; Filush, K.R.; Franco, A.; Fesler, M.C.; Stricker, R.B. Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease. Preprints 2018, 2018030062 (doi: 10.20944/preprints201803.0062.v1). Middelveen, M.J.; Sapi, E.; Burke, J.; Filush, K.R.; Franco, A.; Fesler, M.C.; Stricker, R.B. Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease. Preprints 2018, 2018030062 (doi: 10.20944/preprints201803.0062.v1). 
 
Abstract 

Introduction: Lyme disease is a tickborne illness that generates controversy among medical providers and researchers. One of the key topics of debate is the existence of persistent infection with the Lyme spirochete, Borrelia burgdorferi, in patients who have been treated with recommended doses of antibiotics yet remain symptomatic. Persistent spirochetal infection despite antibiotic therapy has recently been demonstrated in non-human primates. We present evidence of persistent Borrelia infection despite antibiotic therapy in patients with ongoing Lyme disease symptoms. 

Materials & Methods: In this pilot study, culture of body fluids and tissues was performed in a randomly selected group of 12 patients with persistent Lyme disease symptoms who had been treated or who were being treated with antibiotics. Cultures were also performed on a group of 10 control subjects without Lyme disease. The cultures were subjected to corroborative microscopic, histopathological and molecular testing for Borrelia organisms in four independent laboratories in a blinded manner. Results: Motile spirochetes identified histopathologically as Borrelia were detected in culture specimens, and these spirochetes were genetically identified as Borrelia burgdorferi by three distinct polymerase chain reaction (PCR) methods. Spirochetes identified as Borrelia burgdorferi were cultured from the blood of seven subjects, from the genital secretions of ten subjects, and from a skin lesion of one subject. Cultures from control subjects without Lyme disease were negative for Borrelia using these methods. 

Conclusions: Using multiple corroborative detection methods, we showed that patients with persistent Lyme disease symptoms may have ongoing spirochetal infection despite antibiotic treatment, similar to findings in non-human primates. The optimal treatment for persistent Borrelia infection remains to be determined. 

Subject Areas Lyme disease; Borrelia burgdorferi; Tickborne disease; Chronic infection; Spirochete culture 

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 
 
 

Thursday, March 8, 2018

Upcoming Lyme Conference for Patients in N. Cal


MyLymeData2018: Seeking Cures Together

San Ramon, CA April 7, 1-5 pm

Speakers:

Award-winning investigative journalist Mary Beth Pfeiffer will discuss her new book, Lyme: The First Epidemic of Climate Change.

When you register, you have the option of pre-ordering a copy of her book. It will be delivered to you when you arrive at the conference, so you'll have the opportunity to have it signed by the author.

LymeDisease.org's Lorraine Johnson will present the latest results from MyLymeData's 10,000 participants, along with a preview of what's next for this important research project.

Dr. Ray Stricker will walk us through many of the new tests for diagnosing Lyme disease that are now on the horizon.

Dr. Christine Green will offer insights into pain-related issues in Lyme disease, along with how to cope with Herxheimer reactions.

For more information:

http://events.r20.constantcontact.com/register/event?oeidk=a07ef2vo92h1445fa6e&llr=xsuluhcab&showPage=true

This event is always good, and comfortable setting, too. A good place to meet other Lyme patients and to hear about the latest in Lyme diagnosis and treatment. I encourage everyone to attend. Bring friends and family, too, especially if they are dubious about your diagnosis and treatment. It is very edcational. 

-Bob


Monday, February 26, 2018

Find a Lyme doctor, and latest updates in the 'Lyme wars' between ILADS and IDSA

I noticed some news posts on Lymedisease.org and thought I should mention them and send everyone a link:


Among other things, there is a Lyme symptom checker, an update to a New York TV station's series called "The Lyme Wars" that first aired Oct of 2017, and a list of Lyme-Literate-Medical-Doctors (LLMDs) on the page. 

-Bob

Wednesday, February 14, 2018

Oxford Diagnostics Laboratories Imugen test for Lyme and Co-Infections

The company has lots of websites.











Over 25 years ago, a small team of Massachusetts Department of Public Health State Laboratory employees, working alongside leading clinicians in the emerging area of Lyme disease, recognized that the diagnostic tools available to physicians and laboratories were limited. This motivated team knew patients deserved better and in 1989 founded Imugen. The roots of Imugen began in providing fast, trusted and accessible testing for evidence of Borrelia burgdorferi infection, the infection that causes Lyme disease. Over time, these founding principles have been applied to other tick-borne infections and have grown to represent a menu of Imugen testing services.

Innovation remains embedded in Imugen's testing services, with progressive PCR and serology test offerings. This comprehensive testing including PCR and serology may offer a greater opportunity to detect evidence of tick-borne infection.* Other innovations include a robust, internal database of infection positivity rates by region, the identification of Borrelia miyamotoi infection in the first clinical case in the United States in 2012 and, most recently, the completion of a three-year clinical trial to evaluate a testing algorithm for detecting Babesia microti in donated blood.

In 2016, Imugen became part of the Oxford Immunotec family through an acquisition. Testing services are being expanded beyond the Northeast to provide clinicians across the United States with comprehensive testing solutions for tick-borne infections.


Clinical Trial: https://clinicaltrials.gov/ct2/show/NCT03201042    (See contact people at the end of the page noting its immunotec)


Oxford Immunotec Announces Update in Patent Infringement Litigation

"While we are disappointed that the court did not grant a preliminary injunction prohibiting the sale of Qiagen's QFT-Plus product in the U.S. before trial, we are encouraged by the court's rulings on the issues of validity and obviousness," said Dr. Peter Wrighton-Smith, Chief Executive Officer of Oxford Immunotec. "We continue to look forward to the further defense of our patents at the upcoming trial in January."

Oxford Immunotec and QIAGEN N.V. Settle Patent Infringement Lawsuit

Thursday, February 1, 2018

Blood test finds toxic Alzheimer's proteins

This is big deal! Apparently there is a new technique for diagnosing Alzheimer's disease years before symptoms such as memory loss and dementia manifest.

-Bob

Blood test finds toxic Alzheimer's proteins - http://www.bbc.co.uk/news/health-42878721