tag:blogger.com,1999:blog-17827546713420949962024-03-13T03:03:19.911-07:00Bob Cowart's BlogLyme disease and Parkinson's diseaseBobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.comBlogger1250125tag:blogger.com,1999:blog-1782754671342094996.post-7009815657798817012021-04-16T08:30:00.000-07:002021-04-16T08:31:00.180-07:00Gut Microbiome Impacts Sleep Quality <div dir="ltr">check this out. <div><br></div><div>Vit B6 shortage (can hppen from sinement, as we know) resulting in poor sleep, low serotonin (depression) </div><div><br></div><div>https://www.naturalhealth365.com/sleep-gut-microbiome-3699.html <br><br><div> <span class="Apple-style-span" style="border-collapse: separate; color: rgb(0, 0, 0); font-family: 'Trebuchet MS'; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; border-spacing: 0px; -webkit-text-decorations-in-effect: none; -webkit-text-stroke-width: 0px;"><div style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;"><br></div><div style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;"><br></div></span></div></div></div>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-4283234676607843372021-04-16T07:49:00.001-07:002021-04-16T07:49:59.775-07:00Early Results from First-In-U.S. Trial of CRISPR-Edited Immune Cells for Cancer Patients Suggest Safety of Approach - Penn Medicine<div dir="ltr"><span>This is not Breaking news but it is just coming to my attention now and is very exciting news. </span><br><span></span><br></div><div dir="ltr"><a href="https://www.pennmedicine.org/news/news-releases/2019/november/results-first-us-trial-crispr-edited-immune-cells-cancer-patients-safety-of-approach">https://www.pennmedicine.org/news/news-releases/2019/november/results-first-us-trial-crispr-edited-immune-cells-cancer-patients-safety-of-approach</a></div><div dir="ltr"><span><br></span></div>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-10776194141092396072021-04-16T07:37:00.001-07:002021-04-16T07:37:30.600-07:00Positive results in first-in-U.S. trial of CRISPR-edited immune cells | Penn TodayThis is GIANT news for anybody with cancer. Check this out! Finally using genetic editing to prime a patient's immune system to target individual specific cancer cells. This is super-targeted immunotherapy. This could illuminate any collateral damage from cancer treatment.
<br>
<br><a href="https://penntoday.upenn.edu/news/positive-results-first-us-trial-crispr-edited-immune-cells">https://penntoday.upenn.edu/news/positive-results-first-us-trial-crispr-edited-immune-cells</a>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-70488092997437132782021-04-07T14:07:00.001-07:002021-04-07T14:07:50.515-07:00THE GUARDIAN: Rates of Parkinson’s disease are exploding. A common chemical may be to blame<div dir="ltr"><br><strong>Rates of Parkinson's disease are exploding. A common chemical may be to blame</strong><br>Researchers believe a factor is a chemical used in drycleaning and household products such as shoe polishes and carpet cleaners<p>Read in The Guardian: <a href="https://apple.news/APus3XvK8S26MAHTygHGTvw">https://apple.news/APus3XvK8S26MAHTygHGTvw</a></p></div>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-37509607188164045372021-04-03T08:59:00.001-07:002021-04-03T08:59:37.502-07:00PATIENT WORTHY: NYC's Cohen Center Established to Offer Dedicated Lyme Disease Treatment<div dir="ltr"><br><strong>NYC's Cohen Center Established to Offer Dedicated Lyme Disease Treatment</strong><br>Lyme disease, and other tick-borne illnesses, can cause intense and prolonged symptoms. In fact, some patients experience chronic symptoms for a number of years following the initial bite. However, there is little expertise on how to effectively treat these chronic and sometimes debilitating symptoms. Now, a $16M grant from the Steven & Alexandra Cohen […] The post NYC's Cohen Center Established to Offer Dedicated Lyme Disease Treatment appeared first on Patient Worthy.<p>Read in Patient Worthy: <a href="https://apple.news/AwVuPLdWVSzGSOsdkNPU1dg">https://apple.news/AwVuPLdWVSzGSOsdkNPU1dg</a></p><p><br>Shared from <a href="https://www.apple.com/news">Apple News</a></p></div><br><br><div dir="ltr"><span style="background-color: rgba(255, 255, 255, 0);">•••••••••••••••••••••••••••••••••••••••••••••<br>Bob Cowart<br>Email: <a href="mailto:bob@cowart.com">bob@cowart.com</a><br>Phone: <a href="tel:510-540-6667" x-apple-data-detectors="true" x-apple-data-detectors-type="telephone" x-apple-data-detectors-result="4/2">510-540-6667</a><br>Books: <a href="http://www.amazon.com/Robert-Cowart/e/B001HOJ3ZQ">http://www.amazon.com/Robert-Cowart/e/B001HOJ3ZQ</a><br>Blog: <a href="http://bobcowart.blogspot.com/">http://bobcowart.blogspot.com</a> <br>Twitter: @bobcowart</span></div>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-1987554180545122882020-11-15T07:09:00.001-08:002020-11-15T07:09:28.650-08:00Horowitz: Dapsone + doxy + rifampin very effective for chronic Lyme<div dir="ltr"><div class="blog-date-wrapper" style="box-sizing: inherit; margin: 0px 20px 0px 0px; padding-top: 0px; padding-bottom: 0px; padding-left: 2px; border: 0px rgb(227, 227, 227); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: 1; vertical-align: baseline; text-align: center; float: left; width: 44px; position: absolute; top: 0px; padding-right: 6px !important;"><div class="blog-month-value" style="text-align: start; box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-weight: 700; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><br></div><div class="blog-month-value" style="text-align: start; box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-weight: 700; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><br></div><div class="blog-month-value" style="text-align: start; box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-weight: 700; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><br></div><div class="blog-month-value" style="text-align: start; box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-weight: 700; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><br></div></div><div class="blog-content-wrapper" style="box-sizing: inherit; margin: 0px; padding: 0px 0px 24px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline; overflow: hidden;"><div class="featured-image" style="box-sizing: inherit; margin: 12px auto 10px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline; float: none; width: 300px; text-align: center; max-width: 100%; height: auto;"><div style="text-align: start;"><span style="background-color: rgba(255, 255, 255, 0);"><img width="249" height="254" src="https://www.lymedisease.org/wp-content/uploads/2019/03/horowitz3.jpg" class="attachment-large size-large wp-post-image lazyloaded" alt="Dr. Richard Horowitz" data-ll-status="loaded" scale="0" style="font-style: inherit; font-variant-caps: inherit; box-sizing: inherit; margin: 0px; padding: 0px; border: 1px solid rgb(230, 230, 230); font-stretch: inherit; line-height: inherit; vertical-align: baseline; max-width: 99%; height: auto; float: none; width: 297px;"></span></div><div class="blog-content" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><p style="text-align: start; box-sizing: inherit; margin: 0px 0px 20px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><span style="background-color: rgba(255, 255, 255, 0);"><br></span></p><p style="text-align: start; box-sizing: inherit; margin: 0px 0px 20px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><span style="background-color: rgba(255, 255, 255, 0);">Hey everyone. This looks like fantastic news for chronic Lyme sufferers everywhere. Something to celebrate! Thank you, Dr. Horowitz!!</span></p><p style="text-align: start; box-sizing: inherit; margin: 0px 0px 20px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;">-Bob</p><p style="text-align: start; box-sizing: inherit; margin: 0px 0px 20px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><br></p><p style="text-align: start; box-sizing: inherit; margin: 0px 0px 20px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><span style="background-color: rgba(255, 255, 255, 0);">A groundbreaking <span style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;">in vivo</span> clinical study conducted by Dr. Richard Horowitz has found that an eight-week course of the leprosy drug dapsone combined with doxycycline and rifampin is effective in improving symptoms in 98% of patients suffering from chronic Lyme disease/Post Treatment Lyme Disease Syndrome (PTLDS).</span></p><p style="text-align: start; box-sizing: inherit; margin: 0px 0px 20px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><span style="background-color: rgba(255, 255, 255, 0);">Dapsone not only acts as a 'persister' drug, but also lowers inflammation, has anti-malarial effects, and can be effective in an autoimmune illness.</span></p><p style="text-align: start; box-sizing: inherit; margin: 0px 0px 20px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><span style="background-color: rgba(255, 255, 255, 0);">These are all clinical manifestations that can be seen in chronic Lyme disease with associated co-infections like <span style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;">Babesia</span> (a malarial-like parasite) and <span style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;">Bartonella </span>(an intracellular bacterium).</span></p><h2 style="text-align: start; box-sizing: inherit; margin: 0px 0px 8px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-weight: 400; font-stretch: inherit; line-height: 1.3; vertical-align: baseline;"><span style="font-size: 21px; background-color: rgba(255, 255, 255, 0);">58% stay in remission after one year</span></h2><p style="text-align: start; box-sizing: inherit; margin: 0px 0px 20px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><span style="background-color: rgba(255, 255, 255, 0);">After using this novel oral, generic antibiotic protocol, 58 percent of those with a history of PTLDS remained in remission for one year or longer, providing new hope for those suffering from chronic Lyme disease. Until now, no treatment has been available for PTLDS. The study is published today in the peer-reviewed journal <span style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><a href="https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.3390%2Fantibiotics9110725&esheet=52315819&newsitemid=20201028005873&lan=en-US&anchor=Antibiotics&index=1&md5=9cf9c4717ae746ef92999b17eb397449" target="_blank" rel="nofollow noopener" shape="rect" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline; text-decoration: none; transition: color 300ms, background-color 300ms, opacity 300ms;">Antibiotics</a>.</span></span></p><p style="text-align: start; box-sizing: inherit; margin: 0px 0px 20px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><span style="background-color: rgba(255, 255, 255, 0);">Lyme borreliosis is a worldwide epidemic, which can result in disabling chronic fatigue, musculoskeletal pain, and neuropsychiatric complaints. Between 300,000 and 500,000 new Lyme disease cases are diagnosed in the U.S. every year, with an estimated 2 million individuals suffering from PTLDS.</span></p><p style="text-align: start; box-sizing: inherit; margin: 0px 0px 20px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><span style="background-color: rgba(255, 255, 255, 0);">Prior National Institute of Health (NIH) trials have shown that symptoms of chronic Lyme disease can be as severe as chronic congestive heart failure, leading to long-term suffering and disability, elevated healthcare costs, and financial insecurity.</span></p><p style="text-align: start; box-sizing: inherit; margin: 0px 0px 20px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><span style="background-color: rgba(255, 255, 255, 0);">Insurance companies have usually denied the persistence of Lyme bacteria after standard antibiotic therapies. This frequently leads to a denial of long-term treatment and lack of access to care for chronically ill patients, who are left without answers as to the etiology of their long-term illness.</span></p><h2 style="text-align: start; box-sizing: inherit; margin: 0px 0px 8px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-weight: 400; font-stretch: inherit; line-height: 1.3; vertical-align: baseline;"><span style="font-size: 21px; background-color: rgba(255, 255, 255, 0);">Persister forms of Lyme bacteria</span></h2><p style="text-align: start; box-sizing: inherit; margin: 0px 0px 20px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><span style="background-color: rgba(255, 255, 255, 0);">During the past decade, new research from Stanford University, Johns Hopkins University, and the University of New Haven have shown the presence of novel biofilm forms and 'persister' forms of <span style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;">Borrelia </span>in culture, which potentially explains treatment resistance and relapse.</span></p><p style="text-align: start; box-sizing: inherit; margin: 0px 0px 20px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><span style="background-color: rgba(255, 255, 255, 0);">A recent study published in the <a href="https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fbmcresnotes.biomedcentral.com%2Farticles%2F10.1186%2Fs13104-020-05298-6&esheet=52315819&newsitemid=20201028005873&lan=en-US&anchor=Springer+journal+BMC+Research+Notes&index=2&md5=6c58ed0ac24cb9c03cc8ce3da4411e3f" target="_blank" rel="nofollow noopener" shape="rect" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline; text-decoration: none; transition: color 300ms, background-color 300ms, opacity 300ms;">Springer journal BMC Research Notes</a>, conducted by University of New Haven researchers and Dr. Richard Horowitz, showed how the bacteria that causes Lyme disease,<span style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"> Borrelia burgdorferi</span>, forms biofilms that protect the organism, and that dapsone combination therapy was one of the most effective treatments against the biofilm form of the bacteria.</span></p><p style="text-align: start; box-sizing: inherit; margin: 0px 0px 20px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><span style="background-color: rgba(255, 255, 255, 0);">This study helps identify dapsone's novel mechanism, which explains in part its effectiveness in relieving resistant symptoms in chronic Lyme disease. The follow-up clinical study demonstrated that combining antibiotics including a tetracycline with older leprosy drugs, e.g., rifampin and dapsone, led to a 98% improvement and 45% long term remission rate in all patients.</span></p><p style="text-align: start; box-sizing: inherit; margin: 0px 0px 20px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><span style="background-color: rgba(255, 255, 255, 0);">Both studies were funded by the MSIDS Research Foundation (MRF) which supports research for causes, treatments, and possible cures of tick-borne and other vector-borne illnesses, as well as the causes, treatments, and possible cures of other acute and chronic diseases.</span></p><p style="text-align: start; box-sizing: inherit; margin: 0px 0px 20px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><span style="background-color: rgba(255, 255, 255, 0);"><span style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;">"</span>The next step is to perform a randomized, placebo-controlled trial using double dose dapsone combination therapy (DDS CT), done in parallel with studies to find answers for resistant tickborne co-infections," said Dr. Richard Horowitz. "The goal is to decisively prove that the elusive "cure" for Lyme disease that has evaded researchers and clinicians for decades may now finally be within reach, curing the suffering of millions of patients worldwide."</span></p><h2 style="text-align: start; box-sizing: inherit; margin: 0px 0px 8px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-weight: 400; font-stretch: inherit; line-height: 1.3; vertical-align: baseline;"><span style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline; font-size: 21px; background-color: rgba(255, 255, 255, 0);">Dr. Richard Horowitz</span></h2><p style="text-align: start; box-sizing: inherit; margin: 0px 0px 20px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><span style="background-color: rgba(255, 255, 255, 0);">Dr. Richard Horowitz is a board-certified internist and medical director of the Hudson Valley Healing Arts Center, specializing in the treatment of tick-borne disorders. He has treated over 13,000 chronic Lyme disease patients in the past 30 years and was a member of the U.S. Department of Health and Human Services (HHS) Tick-borne Disease Working Group and co-chair of the HHS Other Tick-borne Diseases and Co-infections subcommittee that provided Congress with recommendations on tick-borne illness. He is presently serving on the HHS Babesia and Tick-borne Pathogens subcommittee. His latest book "How Can I Get Better? An Action Plan for Treating Resistant Lyme and Chronic Disease" explains his comprehensive approach to treating resistant chronic illness.</span></p><h2 style="text-align: start; box-sizing: inherit; margin: 0px 0px 8px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-weight: 400; font-stretch: inherit; line-height: 1.3; vertical-align: baseline;"><span style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline; font-size: 21px; background-color: rgba(255, 255, 255, 0);">MSIDS Research Foundation (MRF)</span></h2><p style="text-align: start; box-sizing: inherit; margin: 0px 0px 20px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><font color="#000000"><span style="caret-color: rgb(0, 0, 0); background-color: rgba(255, 255, 255, 0);"><a href="https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fwww.msidsfoundation.com%2Fabout&esheet=52315819&newsitemid=20201028005873&lan=en-US&anchor=MRF&index=3&md5=deca0ad8defd951928a9b3f49a475940" target="_blank" rel="nofollow noopener" shape="rect" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline; text-decoration: none; transition: color 300ms, background-color 300ms, opacity 300ms;">MRF</a> was formed for the purposes of researching the causes, treatments, and possible cures of tick-borne and other vector-borne illnesses, as well as the causes, treatments, and possible cures of other acute and chronic diseases. The goal of the MRF is to disseminate research and expand scientific knowledge for the benefit of all who suffer from acute and chronic illnesses.</span></font></p><p style="text-align: start; box-sizing: inherit; margin: 0px 0px 20px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><span style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline; background-color: rgba(255, 255, 255, 0);">Related Studies</span></p><ul class="bwlistdisc" style="box-sizing: inherit; margin: -8px 0px 20px 20px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline; list-style-position: initial; list-style-image: initial;"><li style="text-align: start; box-sizing: inherit; margin: 12px 0px 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: 24px; vertical-align: baseline;"><span style="background-color: rgba(255, 255, 255, 0);">The <a href="https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.1186%2Fs13104-020-05298-6&esheet=52315819&newsitemid=20201028005873&lan=en-US&anchor=Springer+study&index=4&md5=51e16875f1fcda1b588a8f0eb264dfa8" target="_blank" rel="nofollow noopener" shape="rect" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline; text-decoration: none; transition: color 300ms, background-color 300ms, opacity 300ms;">Springer study</a> showed that higher doses of dapsone were more effective in culture against the biofilm forms of <span style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;">Borrelia</span> (Horowitz, R.I., Murali, K., Gaur, G. et al. Effect of dapsone alone and in combination with intracellular antibiotics against the biofilm form of B. burgdorferi. BMC Res Notes 13, 455 (2020).</span></li><li style="text-align: start; box-sizing: inherit; margin: 12px 0px 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: 24px; vertical-align: baseline;"><span style="background-color: rgba(255, 255, 255, 0);"><span style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><a href="https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.3390%2Fantibiotics9110725&esheet=52315819&newsitemid=20201028005873&lan=en-US&anchor=Antibiotics&index=5&md5=80821d1b1d86c2c2a23e3138520c70b9" target="_blank" rel="nofollow noopener" shape="rect" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline; text-decoration: none; transition: color 300ms, background-color 300ms, opacity 300ms;">Antibiotics</a></span> (Efficacy of Double-Dose Dapsone Combination Therapy in the Treatment of Chronic Lyme Disease/Post-Treatment Lyme Disease Syndrome (PTLDS) and Associated Co-infections: A Report of Three Cases and Retrospective Chart Review. Antibiotics, accepted Oct 21, 2020.</span></li><li style="text-align: start; box-sizing: inherit; margin: 12px 0px 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: 24px; vertical-align: baseline;"><span style="background-color: rgba(255, 255, 255, 0);">Retrospective study on 200 patients who improved on dapsone combination therapy (Horowitz, R.I.; Freeman, P.R. Precision Medicine: retrospective chart review and data analysis of 200 patients on dapsone combination therapy for chronic Lyme disease/post-treatment Lyme disease syndrome: part 1.<span style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><a href="https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F30863136&esheet=52315819&newsitemid=20201028005873&lan=en-US&anchor=International+Journal+of+General+Medicine&index=6&md5=8ae1aaf463d1b015c83e19b9ecf7f879" target="_blank" rel="nofollow noopener" shape="rect" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline; text-decoration: none; transition: color 300ms, background-color 300ms, opacity 300ms;">International Journal of General Medicine</a> </span>2019:<a href="tel:12 101%E2%80%93119" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline; text-decoration: none; transition: color 300ms, background-color 300ms, opacity 300ms;">12 101–119</a>. Horowitz, R.I.; Freeman, P.R.</span></li><li style="text-align: start; box-sizing: inherit; margin: 12px 0px 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: 24px; vertical-align: baseline;"><span style="background-color: rgba(255, 255, 255, 0);"><span style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><a href="https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F30400667&esheet=52315819&newsitemid=20201028005873&lan=en-US&anchor=Precision+Medicine%3A&index=7&md5=0491568fd099c35890bd2477fffe3902" target="_blank" rel="nofollow noopener" shape="rect" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline; text-decoration: none; transition: color 300ms, background-color 300ms, opacity 300ms;">Precision Medicine:</a></span> The Role of the MSIDS Model in Defining, Diagnosing, and Treating Chronic Lyme Disease/Post Treatment Lyme Disease Syndrome and Other Chronic Illness: Part 2. Healthcare 2018, 6, 129. <a href="https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F30400667&esheet=52315819&newsitemid=20201028005873&lan=en-US&anchor=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F30400667&index=8&md5=c71b8f4f6d9afb054cbf534bcd8199f5" target="_blank" rel="nofollow noopener" shape="rect" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline; text-decoration: none; transition: color 300ms, background-color 300ms, opacity 300ms;">https://www.ncbi.nlm.nih.gov/pubmed/30400667</a>; Horowitz RI, Freeman PR (2016).</span></li><li style="text-align: start; box-sizing: inherit; margin: 12px 0px 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: 24px; vertical-align: baseline;"><span style="background-color: rgba(255, 255, 255, 0);">Retrospective study on 100 patients who improved on dapsone combination therapy (The Use of Dapsone as a Novel "Persister" Drug in the Treatment of Chronic Lyme Disease/Post Treatment Lyme Disease Syndrome. J Clin Exp Dermatol Res 7: 345. doi:10.4172/2155-9554.1000345).</span></li></ul><p style="text-align: start; box-sizing: inherit; margin: 0px 0px 20px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><span style="background-color: rgba(255, 255, 255, 0);">Source of press release: <a href="https://www.msidsfoundation.com/about" target="_blank" rel="noopener" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline; text-decoration: none; transition: color 300ms, background-color 300ms, opacity 300ms;"><span style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-weight: 900; font-stretch: inherit; line-height: inherit; vertical-align: baseline;">MSIDS Research Foundation</span></a></span></p><div class="yarpp-related" style="box-sizing: inherit; margin: 1em 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline;"><h3 style="text-align: start; box-sizing: inherit; margin: 0px 0px 7px; padding: 0px 0px 5px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-weight: 400; font-stretch: inherit; line-height: 1.4; vertical-align: baseline;"><span style="font-size: 21px; background-color: rgba(255, 255, 255, 0);">Related Posts:</span></h3><ol style="box-sizing: inherit; margin: 6px 0px 20px 20px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: baseline; list-style: none; counter-reset: li 0;"><li style="text-align: start; box-sizing: inherit; margin: 12px 0px 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: 24px; vertical-align: baseline; counter-increment: li 1;"><a href="https://www.lymedisease.org/touched-by-lyme-dapsone/" rel="bookmark" title="TOUCHED BY LYME: Leprosy drug shows promise for Lyme treatment" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-weight: 700; font-stretch: inherit; line-height: inherit; vertical-align: baseline; text-decoration: none; transition: color 300ms, background-color 300ms, opacity 300ms; caret-color: rgb(0, 0, 0); background-color: rgba(255, 255, 255, 0);"><font color="#000000">TOUCHED BY LYME: Leprosy drug shows promise for Lyme treatment </font></a></li><li style="text-align: start; box-sizing: inherit; margin: 12px 0px 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: 24px; vertical-align: baseline; counter-increment: li 1;"><a href="https://www.lymedisease.org/horowitz-aonm-talk-covid19/" rel="bookmark" title="Horowitz: Reducing inflammation can head off serious COVID complications" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-weight: 700; font-stretch: inherit; line-height: inherit; vertical-align: baseline; text-decoration: none; transition: color 300ms, background-color 300ms, opacity 300ms; caret-color: rgb(0, 0, 0); background-color: rgba(255, 255, 255, 0);"><font color="#000000">Horowitz: Reducing hinflammation can head off serious COVID complications </font></a></li><li style="text-align: start; box-sizing: inherit; margin: 12px 0px 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: 24px; vertical-align: baseline; counter-increment: li 1;"><a href="https://www.lymedisease.org/horowitz-couric-oct9/" rel="bookmark" title="Horowitz talks Lyme with Katie Couric Oct 9; he'll be at San Diego Lymewalk Oct. 19" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-weight: 700; font-stretch: inherit; line-height: inherit; vertical-align: baseline; text-decoration: none; transition: color 300ms, background-color 300ms, opacity 300ms; caret-color: rgb(0, 0, 0); background-color: rgba(255, 255, 255, 0);"><font color="#000000">Horowitz talks Lyme with Katie Couric Oct 9; he'll be at San Diego Lymewalk Oct. 19 </font></a></li><li style="text-align: start; box-sizing: inherit; margin: 12px 0px 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: 24px; vertical-align: baseline; counter-increment: li 1;"><a href="https://www.lymedisease.org/horowitz-couric-oct9-2/" rel="bookmark" title="NEWS: Horowitz talks Lyme with Katie Couric Oct 9; he'll be at San Diego Lymewalk Oct. 19" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px rgb(230, 230, 230); font-style: inherit; font-variant-caps: inherit; font-weight: 700; font-stretch: inherit; line-height: inherit; vertical-align: baseline; text-decoration: none; transition: color 300ms, background-color 300ms, opacity 300ms; caret-color: rgb(0, 0, 0); background-color: rgba(255, 255, 255, 0);"><font color="#000000">NEWS: Horowitz talks Lyme with Katie Couric Oct 9; he'll be at San Diego Lymewalk Oct. 19</font></a></li></ol></div></div></div></div></div>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-17537138412584899162020-09-30T07:33:00.001-07:002020-09-30T07:33:52.906-07:00Vitamin D levels appear to play role in COVID-19 mortality<p style="margin: 0px; font-stretch: normal; font-size: 12px; line-height: normal; font-family: Helvetica;"><span style="background-color: rgba(255, 255, 255, 0);">Vitamin D levels appear to play role in COVID-19 mortality rates: Patients with severe deficiency are twice as likely to experience major complications</span></p><p style="margin: 0px; font-stretch: normal; line-height: normal;"><br></p><p style="margin: 0px; font-stretch: normal; line-height: normal;"><span style="background-color: rgba(255, 255, 255, 0);"><a href="https://www.sciencedaily.com/releases/2020/05/200507121353.htm" dir="ltr" x-apple-data-detectors="true" x-apple-data-detectors-type="link" x-apple-data-detectors-result="0">https://www.sciencedaily.com/releases/2020/05/200507121353.htm</a><br><br>Researchers analyzed patient data from 10 countries. The team found a correlation between low vitamin D levels and hyperactive immune systems. Vitamin D strengths innate immunity and prevents overactive immune responses. The finding could explain several mysteries, including why children are unlikely to die from COVID-19.<br><br></span></p>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-22768774556857830962020-09-19T00:23:00.001-07:002020-09-19T00:23:47.995-07:00Stool transplants: A way to bring gut bacteria back to health<h1 class=""><span style="font-weight: normal;" class=""><font size="2" class="">Interesting article about possible linkage between PD and gut biome…. </font></span></h1><h1 class=""><span style="font-size: 14px;" class="">Stool transplants: A way to bring gut bacteria back to health</span></h1><h1 class=""><span style="font-size: 12px;" class="">We often don't like talking about our bowels, but they are of great importance for our overall health. And if they don't work properly, serious problems can occur. Sometimes stool transplants can help. </span></h1><div class=""><p class=""><b class="">What is the correct medical language when talking about human solid body waste? S…? Excrement? Or feces?</b></p><p class=""><b class="">The common name among doctors is stool, says <a href="https://www.dzif.de/en/reconciling-career-and-family-life" target="_blank" class="external icon" rel="nofollow noopener">Maria Vehreschild,</a> the head of Infectiology at the <a href="https://www.kgu.de/einrichtungen/kliniken/zentrum-der-inneren-medizin/medizinische-klinik-2-haematologie-onkologie-haemostaseologie-rheumatologie-infektiologiehiv/infektiologie/" target="_blank" class="external icon" rel="nofollow noopener">University Hospital in Frankfurt,</a> Germany.</b></p><p class=""><b class="">She knows that hardly anyone likes to talk about stool in general and their own in particular. And to even imagine what it would be like to have someone else's stool transplanted into one's own body is probably a rather repulsive idea for most people.</b></p><p class=""><b class="">But patients who are about to undergo a <a href="https://en.wikipedia.org/wiki/Fecal_microbiota_transplant" target="_blank" class="external icon" rel="nofollow noopener">stool transplant</a> are hardly bothered by this, says Vehreschild. After all, it could mean an improvement in their state of health. "The psychological problems of the recipients are mainly caused by the fact that intestinal diseases are usually recurrent. In other words, they come back again and again. This troubles the patients more than anything else," says Vehreschild.</b></p><p class=""><b class="">In addition to her work at the University of Frankfurt...</b></p></div><div class=""><b class="">See the rest of the article….. </b></div><div class=""><b class=""><br class=""></b></div><div class=""><b class=""><a href="https://www.dw.com/en/stool-transplants-a-way-to-bring-gut-bacteria-back-to-health/a-54946345" class="">https://www.dw.com/en/stool-transplants-a-way-to-bring-gut-bacteria-back-to-health/a-54946345</a></b></div><div class=""><b class=""><i class=""><font face="Optima" class=""><br class=""></font></i></b></div><div class=""><br class=""></div><div class=""><br class=""></div><div class=""><br class=""></div><div class=""><br class=""></div>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-18892559650802949742020-09-15T13:41:00.001-07:002020-09-15T13:41:34.331-07:00LYME SCI: What smells like citrus and protects you from ticks?From Lymedisease.org. A new, naturally-derived tick repellent that is effective against Lyme ticks.
<br>
<br><a href="https://www.lymedisease.org/lyme-sci-nootkatone-repellent/">https://www.lymedisease.org/lyme-sci-nootkatone-repellent/</a>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-83243618828699663472020-09-10T19:58:00.001-07:002020-09-10T19:58:16.066-07:00Ivermectin Triple Therapy Protocol for COVID-19 Released to Australian GPs for Infected Elderly and Frontline Workers - FirstWord Pharma<a href="https://www.firstwordpharma.com/node/1750924">https://www.firstwordpharma.com/node/1750924</a>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-62671474663708936922020-08-29T01:45:00.001-07:002020-08-29T01:45:13.172-07:00Treatment of Insomnia in Parkinson’s Disease: A Controlled Trial of Eszopiclone and Placebo<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928867/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928867/</a>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-6445147252260171352020-08-22T07:19:00.001-07:002020-08-22T07:19:36.302-07:00Microdose lithium formulation is capable of halting signs of advanced Alzheimer’s and improving cognition <div dir="ltr"><div dir="ltr"><p class="css-158dogj evys1bk0" style="margin: 0px 0px 0.9375rem; padding: 0px; border: 0px; -webkit-text-size-adjust: 100%; font-family: nyt-imperial, georgia, "times new roman", times, serif; font-size: 1.25rem; font-stretch: inherit; line-height: 1.875rem; vertical-align: baseline; width: 600px; max-width: 100%; caret-color: rgb(51, 51, 51); color: rgb(51, 51, 51);">THE idea of putting a mind-altering drug in the drinking water is the stuff of sci-fi, terrorist plots and totalitarian governments. Considering the outcry that occurred when putting fluoride in the water was first proposed, one can only imagine the furor that would ensue if such a thing were ever suggested. </p><p class="css-158dogj evys1bk0" style="margin: 0px 0px 0.9375rem; padding: 0px; border: 0px; -webkit-text-size-adjust: 100%; font-family: nyt-imperial, georgia, "times new roman", times, serif; font-size: 1.25rem; font-stretch: inherit; line-height: 1.875rem; vertical-align: baseline; width: 600px; max-width: 100%; caret-color: rgb(51, 51, 51); color: rgb(51, 51, 51);">The debate, however, is moot. It's a done deal. Mother Nature has already put a psychotropic drug in the drinking water, and that drug is lithium. Although this fact has been largely ignored for over half a century, it appears to have important medical implications. </p><p class="css-158dogj evys1bk0" style="margin: 0px 0px 0.9375rem; padding: 0px; border: 0px; -webkit-text-size-adjust: 100%; font-family: nyt-imperial, georgia, "times new roman", times, serif; font-size: 1.25rem; font-stretch: inherit; line-height: 1.875rem; vertical-align: baseline; width: 600px; max-width: 100%; caret-color: rgb(51, 51, 51); color: rgb(51, 51, 51);">Lithium is a naturally occurring element, not a molecule like most medications, and it is present in the United States, depending on the geographic area, at concentrations that can range widely, from undetectable to around .170 milligrams per liter. This amount is less than a thousandth of the minimum daily dose given for bipolar disorders and for depression that doesn't respond to antidepressants. Although it seems strange that the microscopic amounts of lithium found in groundwater could have any substantial medical impact, the more scientists look for such effects, the more they seem to discover. Evidence is slowly accumulating that relatively tiny doses of lithium can have beneficial effects. They appear to decrease suicide rates significantly and may even promote brain health and improve mood. </p><p class="css-158dogj evys1bk0" style="margin: 0px; padding: 0px; border: 0px; -webkit-text-size-adjust: 100%; font-family: nyt-imperial, georgia, "times new roman", times, serif; font-size: 1.25rem; font-stretch: inherit; line-height: 1.875rem; vertical-align: baseline; width: 600px; max-width: 100%; caret-color: rgb(51, 51, 51); color: rgb(51, 51, 51);">Yet despite the studies demonstrating the benefits of relatively high natural lithium levels present in the drinking water of certain communities, few seem to be aware of its potential. Intermittently, stories appear in the scientific journals and media, but they seem to have little traction in the medical community or with the general public...</p></div><div dir="ltr"><br></div><div dir="ltr">See full article.</div><div dir="ltr"><div><a href="https://www.nytimes.com/2014/09/14/opinion/sunday/should-we-all-take-a-bit-of-lithium.html">https://www.nytimes.com/2014/09/14/opinion/sunday/should-we-all-take-a-bit-of-lithium.html</a></div></div></div><blockquote type="cite"><div dir="ltr"><div dir="ltr"></div> </div></blockquote>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-66040843058696585852020-08-18T10:42:00.001-07:002020-08-18T10:42:33.794-07:00'Master regulator' may shield the brain from Parkinson's-related damage<div dir="ltr"><div dir="ltr" style="-webkit-text-size-adjust: auto;"><strong>Switching off 'master regulator' may shield the brain from Parkinson's-related damage</strong><br>Dr. Viviane Labrie | Van Andel Institute<br><br>Read in SCIENMAG: <a href="https://apple.news/AUlggauMiR4iOCzHypzUygw">https://apple.news/AUlggauMiR4iOCzHypzUygw</a><br><br></div><br class="Apple-interchange-newline" style="-webkit-text-size-adjust: auto;"></div>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-5781072483499109302020-08-12T23:42:00.001-07:002020-08-12T23:42:20.198-07:00Lyme can cause vocal cord paralysis<br class=""><div class=""><div style="font-family: TrebuchetMS;" class=""><br class=""></div><a href="https://danielcameronmd.com/lyme-disease-added-causes-vocal-cord-paralysis/" style="color: purple; font-family: TrebuchetMS;" class="">https://danielcameronmd.com/lyme-disease-added-causes-vocal-cord-paralysis/</a><div style="font-family: TrebuchetMS;" class=""><br class=""></div><div style="font-family: TrebuchetMS;" class=""><div class="blauth" style="cursor: auto; font-size: 18px; line-height: 1.4; margin: 0px; padding: 0px; font-family: robotobold, arial, sans-serif !important;">By <a href="https://danielcameronmd.com/author/dancameron/" title="Posts by Dr. Daniel Cameron" rel="author" style="color: rgb(0, 0, 0) !important; text-decoration: none; -webkit-transition: all 250ms ease-in-out; transition: all 250ms ease-in-out; cursor: pointer;" class="">Dr. Daniel Cameron</a></div><span style="color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif; font-size: 16px; background-color: rgb(255, 255, 255);" class=""> </span><div class="pdfwrap" style="cursor: auto; margin: -54px 0px 0px; text-align: right; color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif; font-size: 16px;"><a href="https://danielcameronmd.com/wp-content/plugins/kalins-pdf-creation-station/kalins_pdf_create.php?singlepost=po_5508" target="_blank" class="pdfdownlk" style="color: rgb(0, 154, 204) !important; text-decoration: none; -webkit-transition: all 250ms ease-in-out; transition: all 250ms ease-in-out; cursor: pointer;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj38Pt0etoI7Arrg2dnJ9TKRoAj18nnYYZ9kQmKoFipIGeRcSr7iWi8X2Tx32z_Uvu2z_m3lpgFtMkckMx1fat3rnd4nqpJPDU6XDOZNqRMiyUOh5U2DZLpQHqENc5sruN65oV_Z1TYtsZT/s1600/PDF_buttonsm-740269.png"><img src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj38Pt0etoI7Arrg2dnJ9TKRoAj18nnYYZ9kQmKoFipIGeRcSr7iWi8X2Tx32z_Uvu2z_m3lpgFtMkckMx1fat3rnd4nqpJPDU6XDOZNqRMiyUOh5U2DZLpQHqENc5sruN65oV_Z1TYtsZT/s320/PDF_buttonsm-740269.png" border="0" alt="" id="BLOGGER_PHOTO_ID_6860355302882283874" /></a></a></div><p style="margin: 1em 0px; word-wrap: break-word; font-size: 16px; line-height: 25px; color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif;" class="">(Updated: 6/24/19)</p><p style="margin: 1em 0px; word-wrap: break-word; font-size: 16px; line-height: 25px; color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif;" class="">In the <em class="">Prevention</em> article, doctors describe how Lyme disease can impact a person's vocal cords. "Lyme can affect the nerves that are responsible for controlling the muscles in the vocal cords," <a href="https://www.prevention.com/health/health-conditions/a28101153/shania-twain-lyme-disease-throat-surgery/?fbclid=IwAR1oYJV6b6KIA-EFQgEUi5P6xEomiGFSAuV239dSqhGfBmXiN8xr8IwYFH4" style="color: rgb(0, 154, 204) !important; text-decoration: none; -webkit-transition: all 250ms ease-in-out; transition: all 250ms ease-in-out; cursor: pointer;" class="">says Amesh A. Adalja, MD, an infectious disease specialist at Johns Hopkins Center for Health Security.</a> "As a result, someone could technically lose their voice if they had Lyme disease."</p><p style="margin: 1em 0px; word-wrap: break-word; font-size: 16px; line-height: 25px; color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif;" class="">In fact, <a href="https://www.ncbi.nlm.nih.gov/pubmed/27777055" style="color: rgb(0, 154, 204) !important; text-decoration: none; -webkit-transition: all 250ms ease-in-out; transition: all 250ms ease-in-out; cursor: pointer;" class="">a case series published in the <em class="">Journal of Voice</em> </a>identified Lyme disease as one of several causes of vocal cord paralysis, a condition that can dramatically impact patients' lives, affecting voice, swallowing and airway function. [1] Identifying the cause is important, the authors state, in order to treat the condition successfully.</p><p style="margin: 1em 0px; word-wrap: break-word; font-size: 16px; line-height: 25px; color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif;" class="">Vocal cord paralysis can be caused by neurologic and inflammatory conditions, as well as by various infections. "Infectious causes include Lyme disease, West Nile virus, varicella, herpes, Epstein-Barr, syphilis, and others." [1]</p><p style="margin: 1em 0px; word-wrap: break-word; font-size: 16px; line-height: 25px; color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif;" class="">The 2016 case series examined the records of 231 Pennsylvania patients with vocal cord paralysis (or paresis). The authors found that the prevalence of syphilis, myasthenia gravis, and Lyme disease was higher in these patients when compared with the national rate.</p><p style="margin: 1em 0px; word-wrap: break-word; font-size: 16px; line-height: 25px; color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif;" class=""><span style="color: rgb(0, 0, 128);" class=""><a href="https://bit.ly/2X6xxin" style="color: rgb(0, 154, 204) !important; text-decoration: none; -webkit-transition: all 250ms ease-in-out; transition: all 250ms ease-in-out; cursor: pointer;" class=""><span style="color: rgb(47, 53, 63); font-family: robotobold;" class="">Join the conversation on Facebook:</span> Shania Twain lost her ability to sing for several years due to Lyme disease. </a></span></p><p style="margin: 1em 0px; word-wrap: break-word; font-size: 16px; line-height: 25px; color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif;" class="">Several of the patients with vocal cord paralysis had Lyme disease. "A positive Lyme titer with confirmatory Western blot was found in five patients (2.2%). When compared with the 2013 incidence of Lyme disease in Pennsylvania (0.039%), these results were statistically significant (P < 0.0001)." [1] </p><p style="margin: 1em 0px; word-wrap: break-word; font-size: 16px; line-height: 25px; color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif;" class=""><span style="color: rgb(47, 53, 63); font-family: robotobold;" class="">This is not the first time Lyme disease has been associated with vocal cord paralysis.</span> In fact, it is possible that this is an underreported symptom, Adalja tells <em class="">Prevention</em> magazine.</p><p style="margin: 1em 0px; word-wrap: break-word; font-size: 16px; line-height: 25px; color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif;" class=""><a href="https://www.ncbi.nlm.nih.gov/pubmed/25367481" style="color: rgb(0, 154, 204) !important; text-decoration: none; -webkit-transition: all 250ms ease-in-out; transition: all 250ms ease-in-out; cursor: pointer;" class="">Martínez-Balzano and colleague</a> describe the <span style="color: rgb(47, 53, 63); font-family: robotobold;" class="">case of a 90-year-old man</span> who presented with dysphonia and upper and lower extremity weakness on his right side. [2] He also had bilateral vocal cord paralysis and respiratory failure which required a tracheostomy.</p><p style="margin: 1em 0px; word-wrap: break-word; font-size: 16px; line-height: 25px; color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif;" class="">The man tested positive for Lyme disease. "The patient received IV ceftriaxone for 2 weeks, followed by complete recovery of motor and vocal function over 2 months."</p><p style="margin: 1em 0px; word-wrap: break-word; font-size: 16px; line-height: 25px; color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif;" class="">In 2010,<span style="color: rgb(47, 53, 63); font-family: robotobold;" class=""> Martzolff reported two cases</span> of vocal fold paresis secondary to neuroborreliosis. "Both cases resulted in favorable outcomes after antibiotic treatment." [3]</p><p style="margin: 1em 0px; word-wrap: break-word; font-size: 16px; line-height: 25px; color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif;" class="">The authors point out the importance of testing vocal cord paralysis patients for Lyme disease, particularly in those living in endemic regions.</p><p style="margin: 1em 0px; word-wrap: break-word; font-size: 16px; line-height: 25px; color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif;" class="">In 1988, a <span style="color: rgb(47, 53, 63); font-family: robotobold;" class="">45-year-old singer</span> developed a sore throat and general malaise which progressed to hoarseness and left-sided neuralgia. The patient tested positive for Lyme disease and was treated with 3 weeks of doxycycline. "After 14 days of therapy she began to improve and after a few weeks she could speak and sing again," writes Schroeter. [4]</p><p style="margin: 1em 0px; word-wrap: break-word; font-size: 16px; line-height: 25px; color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif;" class="">"We have seen a case where serologically confirmed <em class="">B. burgdorferi</em> infection was associated with paralysis of the recurrent laryngeal nerve," explains Schroeter.</p><p style="margin: 1em 0px; word-wrap: break-word; font-size: 16px; line-height: 25px; color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif;" class="">"Because vocal fold paresis secondary to Lyme disease can be treated easily with antibiotics," explains White, "testing patients with idiopathic vocal fold paresis should be routine, especially in endemic areas or in patients who have traveled to areas in which Lyme disease is endemic." [1]</p><p style="margin: 1em 0px; word-wrap: break-word; font-size: 16px; line-height: 25px; color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif;" class="">White and colleagues did not design their case series to test causality. "Although their causal relationship to vocal fold paralysis or paresis has not been investigated or established by this study, the medical importance of having established these diagnoses and instituted treatment is self-evident, and their possible causal association awaits further study."</p><p style="margin: 1em 0px; word-wrap: break-word; font-size: 16px; line-height: 25px; color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif;" class="">Nevertheless, the authors recommended implementing a comprehensive evaluation to identify serious and treatable causal or associated disorders underlying vocal fold paralysis and paresis.</p><p style="margin: 1em 0px; word-wrap: break-word; font-size: 16px; line-height: 25px; color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif;" class="">The most common causes of this disorder include non-laryngeal malignancies, iatrogenic injuries, and idiopathic causes. Post-operative dysfunction after retraction, dissection along the recurrent laryngeal nerve and thoracic malignancy have also been identified as contributing triggers, explains White.</p><p style="margin: 1em 0px; word-wrap: break-word; font-size: 16px; line-height: 25px; color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif;" class="">Additional causes of vocal cord paralysis include neurologic complications such as myasthenia gravis, severe degenerative spine disease, multiple sclerosis, amyotrophic lateral sclerosis, and Parkinson disease, as well as other disorders, White states.</p><p style="margin: 1em 0px; word-wrap: break-word; font-size: 16px; line-height: 25px; color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif;" class="">Furthermore, inflammatory causes may include sarcoidosis, systemic lupus erythematosus, amyloidosis, and polyarteritis nodosa.</p><p style="margin: 1em 0px; word-wrap: break-word; font-size: 16px; line-height: 25px; color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif;" class="">"Additionally, diabetes, thyroid disease, malnutrition, and vinca alkaloids have been found to cause vocal fold (cord) paralysis or paresis," White explains.</p><p style="margin: 1em 0px; word-wrap: break-word; font-size: 16px; line-height: 25px; color: rgb(80, 80, 80); font-family: robotoregular, arial, sans-serif;" class="">"It is important for clinicians, especially tertiary and quaternary providers, to be familiar with the numerous diseases that may present in association with vocal fold paralysis or paresis," states White, "and to consider comprehensive diagnostic evaluation to identify serious and treatable causal or associated disorders."</p><div class=""><br class=""></div></div></div>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-32518059593607382742020-08-12T18:21:00.001-07:002020-08-12T18:21:10.064-07:00EPA approves Nootkatone to repel ticks<chatitem id="p:0/891035E7-02D9-428D-BAAC-D6165FADE5C1" contiguous="no" chatitem-message="yes" role="presentation" display-type="balloon" item-type="text" group-first-message-ignore-timestamps="no" group-last-message-ignore-timestamps="no" style="width: 479px; display: -webkit-box; -webkit-box-orient: vertical; margin-top: 4px; font-family: Times; background-color: rgb(255, 255, 255);" class=""><message guid="p:0/891035E7-02D9-428D-BAAC-D6165FADE5C1" typing-indicator="no" sent="no" from-me="no" from-system="no" from="F24107AA-E1C9-487A-AECD-052A4C56C679" emote="no" played="no" auto-reply="no" group-first-message="yes" group-last-message="yes" style="display: -webkit-box; -webkit-box-orient: horizontal; position: relative; -webkit-box-direction: normal; -webkit-box-align: end; -webkit-box-pack: start; margin-left: 12px;" class=""><messagetext style="display: -webkit-flex; -webkit-flex-direction: column; word-wrap: break-word; cursor: auto; max-width: 60%; min-width: 33px; min-height: 24px; position: relative; background-color: rgb(229, 229, 234);" class=""><messagebody title="Yesterday, 9:41:11 AM" aria-label="The EPA on Monday approved the use of a chemical that repels and kills mosquitoes and ticks. Nootkatone, an oily compound found in cedar trees and grapefruits, is safe because it is not toxic to humans and many other mammals, as well as fish, birds, and bees. Products containing nootkatone could be used to fight ticks, mosquitoes, and fleas – insects that can pass on many diseases to humans, including malaria and Zika. It may be effective against other pests, including lice, sandflies, and midges. More: In smaller doses, nootkatone repels a variety of insects and in higher doses, it can kill those same insects. Nootkatone can kill bugs that are resistant to some commonly used pesticides, such as DDT and pyrethroids. Unlike other organic insect repellants, such as citronella, peppermint oil, and lemongrass oil, nootkatone has a long-lasting effect." role="text" style="display: -webkit-flex; -webkit-flex: 0 1 auto; padding: 5px 10px 4px 15px;" class=""><messagetextcontainer text-direction="ltr" style="margin-left: auto; margin-right: auto; direction: ltr !important;" class="">Aug 12, 2020<br class=""><div style="margin: 0px; font-family: Helvetica;" class=""><br class=""></div><div style="margin: 0px; font-family: Helvetica;" class="">The EPA on Monday approved the use of a chemical that repels and kills mosquitoes and ticks. Nootkatone, an oily compound found in cedar trees and grapefruits, is safe because it is not toxic to humans and many other mammals, as well as fish, birds, and bees. Products containing nootkatone could be used to fight ticks, mosquitoes, and fleas – insects that can pass on many diseases to humans, including malaria and Zika. It may be effective against other pests, including lice, sandflies, and midges.</div><div style="margin: 0px; font-family: Helvetica; min-height: 14px;" class=""><br class=""></div><div style="margin: 0px; font-family: Helvetica;" class="">More:</div><div style="margin: 0px; font-family: Helvetica; min-height: 14px;" class=""><br class=""></div><div style="margin: 0px; font-family: Helvetica;" class="">In smaller doses, nootkatone repels a variety of insects and in higher doses, it can kill those same insects. </div><div style="margin: 0px; font-family: Helvetica;" class=""><br class=""></div><div style="margin: 0px; font-family: Helvetica;" class="">Nootkatone can kill bugs that are resistant to some commonly used pesticides, such as DDT and pyrethroids. </div><div style="margin: 0px; font-family: Helvetica;" class=""><br class=""></div><div style="margin: 0px; font-family: Helvetica;" class="">Unlike other organic insect repellants, such as citronella, peppermint oil, and lemongrass oil, nootkatone has a long-lasting effect.</div></messagetextcontainer></messagebody></messagetext></message></chatitem><chatitem id="d:6C9F80A6-1640-4C09-B3EE-192DEA09237F" contiguous="no" role="heading" aria-level="2" item-type="timestamp" style="width: 479px; display: -webkit-box; -webkit-box-orient: vertical; margin-top: 9px; font-family: Times; background-color: rgb(255, 255, 255);" class=""><timestamp guid="d:6C9F80A6-1640-4C09-B3EE-192DEA09237F" id="d:6C9F80A6-1640-4C09-B3EE-192DEA09237F" style="display: block; text-align: center; white-space: nowrap; -webkit-user-select: none; cursor: default;" class=""><date date="618905439.000000" style="display: inline-block; font-family: HelveticaNeue-Medium; font-size: 11px; color: rgb(142, 142, 147); margin-left: 3px; margin-right: 3px;" class="">Yesterday, 11:10 PM</date></timestamp></chatitem><chatitem id="p:0/6C9F80A6-1640-4C09-B3EE-192DEA09237F" contiguous="no" chatitem-message="yes" role="presentation" display-type="balloon" item-type="text" group-first-message-ignore-timestamps="no" group-last-message-ignore-timestamps="no" style="width: 479px; display: -webkit-box; -webkit-box-orient: vertical; margin-top: 4px; font-family: Times; background-color: rgb(255, 255, 255);" class=""></chatitem>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-50447340998976459112020-08-01T01:17:00.001-07:002020-08-01T01:17:14.933-07:00Dr Horowitz protocol for treating COVID-19 (overheard)<div class="">Accuracy not guaranteed on this edited repost by me, but I thought I should post this in case anyone is in need of some tips, clues, links for treating COVID-19 cases.</div><div class="">-Bob Cowart</div><div class=""><br class=""></div>Dr. Horowitz is now working with state leaders in hopes of securing state funding to conduct randomized trials.<div class=""><br class=""><b class=""><u class="">The treatment includes three over the counter natural oral supplements called acetyl-cysteine, glutathione and alpha lipoic acid.</u></b><br class=""><font color="#12c00e" face="TrebuchetMS" class=""><br class=""></font>"They block a switch inside the nucleus called NF Capa B, and when this switch gets turned on it turns on all the inflammation and all these inflammatory molecules that you see with COVID-19," says Dr. Horowitz.<br class=""><font color="#12c00e" face="TrebuchetMS" class=""><br class=""></font>Since a vaccine could be months away, Dr. Horowitz says it's time to think outside of the box and try to use natural supplements.<br class=""><div dir="ltr" class=""><div dir="ltr" class=""><div class=""><br class=""></div></div></div><div dir="ltr" class=""><div dir="ltr" class=""><div class=""><div class=""><div dir="ltr" class=""><div class="">Dr. Horowitz is now working with state leaders in hopes of securing state funding to conduct randomized trials.</div></div></div></div></div></div></div><div class=""><br class=""></div><div class="">Does anyone know the doses of the Horowitz protocol? I have recommended 600mg NAC plus selenium 400mcg to increase production of glutathione as well as Liposomal Glutathione orally or injectable Glutathione from a compounding pharmacy if possible. Reports of rapid relief of Covid-19 symptoms with Glutathione are unfortunately only uncontrolled case reports, but that type of response is lifesaving and low risk for adverse effects. Glutathione levels decrease with viral infections and NAC and selenium have been reported to restore levels. Glutathione is an important controller of innate and adaptive immunity, inflammation and reduction of ROS plus it has antiviral effects. Too bad the "standard" treatment approaches are always search for "silver bullets" instead of understanding the pathophysiology of the illness and using methods to correct it.<div class=""><font color="#12c00e" face="TrebuchetMS" class=""><br class=""></font><span style="font-family: TrebuchetMS;" class="">Horowitz spoke about Ivermectin as being current best Rx hope for prevention and early intervention pending double blind placebo controlled trials.</span><br class=""><span style="font-family: TrebuchetMS;" class="">0.2-0.4 mg/kg once a week for two weeks, repeat in 12 weeks (someone said they</span><span style="font-family: TrebuchetMS;" class=""> heard that in one of his latest YouTube interviews).</span></div><div class=""><span style="font-family: TrebuchetMS;" class=""><br class=""></span></div><div class=""><span style="font-family: TrebuchetMS;" class="">Binds to CD157 receptors on RBC and block micro vascular clotting, and prevents Covid19 from entering cell membrane where they shut down immune function.</span><br class=""><font color="#12c00e" face="TrebuchetMS" class=""><br class=""></font><a href="http://westchester.news12.com/story/42383284/hudson-valley-doctor-touts-lyme-disease-treatment-as-option-for-covid19-patients" class="">http://westchester.news12.com/story/42383284/hudson-valley-doctor-touts-lyme-disease-treatment-as-option-for-covid19-patients</a> <br class=""><font color="#12c00e" face="TrebuchetMS" class=""><br class=""></font>Dr. Horowitz has now used the treatment on nearly two dozen coronavirus patients.<br class=""><font color="#12c00e" face="TrebuchetMS" class=""><br class=""></font><br class=""></div></div>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-37798529097939573772020-07-23T13:39:00.001-07:002020-07-23T13:39:36.646-07:00Financial support for Lyme treatmentThanks to Emily in our East Bay (LEAPS) Lyme support group, here is a link about financial assistance for people with Lyme disease. <div><br></div><div><span style="-webkit-text-size-adjust: auto;"><a href="https://globallymealliance.org/financial-assistance/" dir="ltr" x-apple-data-detectors="true" x-apple-data-detectors-type="link" x-apple-data-detectors-result="0" style="color: currentcolor;">https://globallymealliance.org/financial-assistance/</a></span><br><br></div><div>-Bob</div>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-90228091097429833802020-07-21T23:58:00.001-07:002020-07-21T23:58:40.123-07:00Melatonin for Parkinson's Disease<a href="https://healthunlocked.com/parkinsonsmovement/posts/143507411/melatonin-for-parkinsons-disease....finally">https://healthunlocked.com/parkinsonsmovement/posts/143507411/melatonin-for-parkinsons-disease....finally</a>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-15201173611581082932020-07-16T10:44:00.001-07:002020-07-16T10:44:55.991-07:00Another article about PTB and astrocytes cure for Parkinson’s<div class="post-body" style="box-sizing: border-box; line-height: 26px; margin-bottom: 40px; overflow-wrap: break-word; word-wrap: break-word;"><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><a href="https://healthunlocked.com/api/redirect?url=https%3A%2F%2Fwww.yahoo.com%2Flifestyle%2Fparkinsons-disease-cure-treatment-tremor-093219804.html" rel="nofollow ugc" target="_blank" style="box-sizing: border-box; text-decoration: none; line-height: 21px; transition: all 0.5s ease; caret-color: rgb(0, 0, 0); font-size: 21px; background-color: rgba(255, 255, 255, 0);"><font color="#000000">yahoo.com/lifestyle/parkins...</font></a></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">Mice were "cured" of Parkinson's disease after a scientific study took an unexpected turn.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">Scientists from the University of California (UC) in San Diego set out to better understand the role of proteins in connective cells, only to discover a way to transform many different types of cells into neurons.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">Parkinson's comes about when neurons – nerve cells – that produce the chemical messenger dopamine, which regulates movement, die off. Patients typically suffer tremors, slow movement and loss of balance when 80% of dopamine is lost.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">The scientists used this discovery to develop a one-off treatment that eliminated Parkinson's symptoms in mice, raising hopes of a cure down the line.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">Existing treatments aim to ease signs of the disease and improve a patient's quality of life, like via physiotherapy.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">'I was stunned at what I saw'</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">More than 145,000 people over 20 in the UK are thought to have been living with Parkinson's in 2018. In the US, nearly 1 million people have the disease.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">The UC scientists were studying a protein called PTB that turns genes "on or off" within cells.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">In an attempt to better understand how PTB influences cell function, they silenced the protein in the connective tissue cell fibroblasts.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">The fibroblasts were then grown in petri dishes to check for any changes.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">A couple of weeks later, the scientists were surprised to find very few fibroblasts remained, having largely been replaced by neurons.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">In a later experiment, published in the journal Nature, the team discovered brain cells called astrocytes also "turned" into neurons when PTB was silenced.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">"Researchers around the world have tried many ways to generate neurones in the lab, using stem cells and other means, so we can study them better, as well as to use them to replace lost neurones in neurodegenerative diseases," said lead author Dr Xiang-Dong Fu.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">"The fact we could produce so many neurones in such a relatively easy way came as a big surprise".</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">The scientists then turned their attention to Parkinson's.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">Rodents were exposed to a chemical that poisons dopamine-producing neurons, creating symptoms of the disease.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">After silencing PTB, 30% of the mice's astrocytes turned into nerve cells, reaching levels comparable to those in normal rodents.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">These new neurons seemed to grow as normal and even sent connections to other parts of the brain.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">When it came to symptoms, turning off PTB completely restored normal movement in the mice, with just one treatment lasting throughout their life.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">"I was stunned at what I saw," said co-author Dr William Mobley.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">"This whole new strategy for treating neurodegeneration gives hope it may be possible to help even those with advanced disease".</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">Professor David Dexter from Parkinson's UK added: "Cell transplants have, for a long time, aimed to replace lost cells in Parkinson's, but their effectiveness has been limited since they struggle to integrate and function effectively within the brain.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">"This new technique has overcome this major hurdle in mice and opens the door to an exciting new treatment approach, which may be able to reverse Parkinson's in people, in future."</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">The scientists were 'stunned' by the cell changes in the petri dish. </span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">'Critical progress is at stake' due to coronavirus</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">Although promising, much more rigorous testing is required before the approach can be tested in humans.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">The scientists plan to silence PTB in mice with genetic changes that cause Parkinson's-like symptoms, rather than the disease coming about via dopamine poisoning.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">"Advances in technologies like this are vital and this is promising and well-conducted early-stage research, but it is in mice and it's not yet clear whether this approach could be used in people," said Dr Sara Imarisio from Alzheimer's Research UK. </span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">Neurons are also destroyed in Alzheimer's disease.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">"Further research will need to develop a better understanding of the potential adverse effects of converting these cells in this way before we can know whether this technique is even possible in a human brain," said Dr Imarisio.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">Professor Tara Spires-Jones from the University of Edinburgh added: "While the principle of this study is remarkable and promising, it is important to note that it was conducted in mice with group sizes from three to eight and there is a long way to go to translate this into a treatment for people."</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">Nevertheless, the UC team has patented their treatment in the hope it could one day help patients.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">"It's my dream to see this through to clinical trials, to test this approach as a treatment for Parkinson's disease, but also many other diseases where neurones are lost, such as Alzheimer's and Huntington's diseases and stroke," said Dr Fu.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">"Dreaming even bigger, what if we could target PTB to correct defects in other parts of the brain, to treat things like inherited brain defects?</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">"I intend to spend the rest of my career answering these questions."</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">While it all sounds promising, medical research charities in the UK have warned "patients will suffer the consequences" unless they receive government support amid the coronavirus outbreak.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">"Findings like this do highlight the potential of medical research, but critical progress is at stake and it's essential that dementia research is backed by the government throughout the COVID-19 crisis," said Dr Imarisio.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">COVID-19 is the respiratory disease that can be triggered by the coronavirus.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">"Research is the only way we can end the fear, heartbreak and harm that diseases like Parkinson's cause," added Dr Imarisio.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">Prior to the pandemic, Parkinson's UK "knew" a major breakthrough and cure for the disease was "close".</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">Instead, the charity has been forced to "fight for fair treatment and better services" for patients, who are more at risk of coronavirus complications.</span></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 15px;"><span style="background-color: rgba(255, 255, 255, 0);">To maintain this increased support, Parkinson's UK must reportedly raise £95,000 ($118,872) a week for the next three months.</span></p></div><div class="post-tags" style="box-sizing: border-box; margin-bottom: 20px;"></div><div dir="ltr"><br></div>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-54630282699056318422020-07-13T17:14:00.001-07:002020-07-13T17:14:50.325-07:00A Common Cough Syrup Drug Just Passed Another Trial as Parkinson's Treatment<a href="https://www.sciencealert.com/drug-used-in-cough-syrup-for-decades-offers-new-hope-as-parkinson-s-treatment">https://www.sciencealert.com/drug-used-in-cough-syrup-for-decades-offers-new-hope-as-parkinson-s-treatment</a>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-43340265450134180852020-07-07T19:28:00.001-07:002020-07-07T19:28:11.812-07:00How do Lyme and COVID-19 intersect?<div dir="ltr">Here's a good source of info on this complex question. </div><div dir="ltr"><br></div><div dir="ltr"><a href="https://www.lymedisease.org/covid-lyme-intersect-usa-today/">https://www.lymedisease.org/covid-lyme-intersect-usa-today/</a></div>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-41884336453966025162020-06-08T13:26:00.001-07:002020-06-08T13:26:15.326-07:00Genetic insights into the etiology of Parkinson’s disease<div dir="ltr"><div dir="ltr"><span style="font-family: Lora, Palatino, Times, "Times New Roman", serif; caret-color: rgb(34, 34, 34); color: rgb(34, 34, 34); -webkit-text-size-adjust: 100%; font-size: 21px;">Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease</span></div><div dir="ltr"><font color="#222222" face="Lora, Palatino, Times, Times New Roman, serif"><span style="caret-color: rgb(34, 34, 34); font-size: 21px; -webkit-text-size-adjust: 100%;"><br></span></font><div dir="ltr"><div class="c-article-header" style="margin: 0px 0px 40px; padding: 0px; caret-color: rgb(34, 34, 34); color: rgb(34, 34, 34); font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, Oxygen-Sans, Ubuntu, Cantarell, "Helvetica Neue", sans-serif; -webkit-text-size-adjust: 100%;"><ul class="c-author-list js-etal-collapsed js-no-scroll" data-etal="25" data-etal-small="3" data-test="authors-list" data-component-authors-activator="authors-list" style="margin-top: 0px; margin-bottom: 0px; list-style: none; padding: 0px; width: 592.359375px;"><span style="font-size: 17px;"><li class="c-author-list__item" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person" style="margin-left: 0px; display: inline; padding-right: 0px;"><span itemprop="name"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="https://www.nature.com/articles/s41588-020-0610-9#auth-1" style="vertical-align: baseline; text-decoration-skip: objects; text-decoration: none; color: rgb(0, 102, 153);">Julien Bryois</a></span>, </li><li class="c-author-list__item" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person" style="margin-left: 0px; display: inline; padding-right: 0px;"><span itemprop="name"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="https://www.nature.com/articles/s41588-020-0610-9#auth-2" style="vertical-align: baseline; text-decoration-skip: objects; text-decoration: none; color: rgb(0, 102, 153);">Nathan G. Skene</a></span>, </li><li class="c-author-list__item js-smaller-author-etal" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person" style="margin-left: 0px; display: inline; padding-right: 0px;"><span itemprop="name"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="https://www.nature.com/articles/s41588-020-0610-9#auth-3" style="vertical-align: baseline; text-decoration-skip: objects; text-decoration: none; color: rgb(0, 102, 153);">Thomas Folkmann Hansen</a></span>, </li><li class="c-author-list__item js-smaller-author-etal" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person" style="margin-left: 0px; display: inline; padding-right: 0px;"><span itemprop="name"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="https://www.nature.com/articles/s41588-020-0610-9#auth-4" style="vertical-align: baseline; text-decoration-skip: objects; text-decoration: none; color: rgb(0, 102, 153);">Lisette J. A. Kogelman</a></span>, </li><li class="c-author-list__item js-smaller-author-etal" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person" style="margin-left: 0px; display: inline; padding-right: 0px;"><span itemprop="name"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="https://www.nature.com/articles/s41588-020-0610-9#auth-5" style="vertical-align: baseline; text-decoration-skip: objects; text-decoration: none; color: rgb(0, 102, 153);">Hunna J. Watson</a></span>, </li><li class="c-author-list__item js-smaller-author-etal" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person" style="margin-left: 0px; display: inline; padding-right: 0px;"><span itemprop="name"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="https://www.nature.com/articles/s41588-020-0610-9#auth-6" style="vertical-align: baseline; text-decoration-skip: objects; text-decoration: none; color: rgb(0, 102, 153);">Zijing Liu</a></span>, </li><li class="c-author-list__item js-smaller-author-etal" style="margin-left: 0px; display: inline; padding-right: 0px;"><a data-test="author-name" href="https://www.nature.com/articles/s41588-020-0610-9#group-1" style="vertical-align: baseline; text-decoration-skip: objects; text-decoration: none; color: rgb(0, 102, 153);">Eating Disorders Working Group of the Psychiatric Genomics Consortium</a>, </li><li class="c-author-list__item js-smaller-author-etal" style="margin-left: 0px; display: inline; padding-right: 0px;"><a data-test="author-name" href="https://www.nature.com/articles/s41588-020-0610-9#group-2" style="vertical-align: baseline; text-decoration-skip: objects; text-decoration: none; color: rgb(0, 102, 153);">International Headache Genetics Consortium</a>, </li><li class="c-author-list__item js-smaller-author-etal" style="margin-left: 0px; display: inline; padding-right: 0px;"><a data-test="author-name" href="https://www.nature.com/articles/s41588-020-0610-9#group-3" style="vertical-align: baseline; text-decoration-skip: objects; text-decoration: none; color: rgb(0, 102, 153);">23andMe Research Team</a>, </li><li class="c-author-list__item js-smaller-author-etal" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person" style="margin-left: 0px; display: inline; padding-right: 0px;"><span itemprop="name"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="https://www.nature.com/articles/s41588-020-0610-9#auth-315" style="vertical-align: baseline; text-decoration-skip: objects; text-decoration: none; color: rgb(0, 102, 153);">Leo Brueggeman</a></span>, </li><li class="c-author-list__item js-smaller-author-etal" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person" style="margin-left: 0px; display: inline; padding-right: 0px;"><span itemprop="name"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="https://www.nature.com/articles/s41588-020-0610-9#auth-316" style="vertical-align: baseline; text-decoration-skip: objects; text-decoration: none; color: rgb(0, 102, 153);">Gerome Breen</a></span>, </li><li class="c-author-list__item js-smaller-author-etal" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person" style="margin-left: 0px; display: inline; padding-right: 0px;"><span itemprop="name"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="https://www.nature.com/articles/s41588-020-0610-9#auth-317" style="vertical-align: baseline; text-decoration-skip: objects; text-decoration: none; color: rgb(0, 102, 153);">Cynthia M. Bulik</a></span>, </li><li class="c-author-list__item js-smaller-author-etal" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person" style="margin-left: 0px; display: inline; padding-right: 0px;"><span itemprop="name"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="https://www.nature.com/articles/s41588-020-0610-9#auth-318" style="vertical-align: baseline; text-decoration-skip: objects; text-decoration: none; color: rgb(0, 102, 153);">Ernest Arenas</a></span>, </li><li class="c-author-list__item js-smaller-author-etal" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person" style="margin-left: 0px; display: inline; padding-right: 0px;"><span itemprop="name"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="https://www.nature.com/articles/s41588-020-0610-9#auth-319" data-corresp-id="c1" style="vertical-align: baseline; text-decoration-skip: objects; text-decoration: none; color: rgb(0, 102, 153);">Jens Hjerling-Leffler<svg width="16" height="16" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#global-icon-email"></use></svg></a></span> & </li><li class="c-author-list__item" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person" style="margin-left: 0px; display: inline; padding-right: 0px;"><span itemprop="name"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="https://www.nature.com/articles/s41588-020-0610-9#auth-320" data-corresp-id="c2" style="vertical-align: baseline; text-decoration-skip: objects; text-decoration: none; color: rgb(0, 102, 153);">Patrick F. Sullivan<svg width="16" height="16" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#global-icon-email"></use></svg></a></span> </li></span><p class="c-article-info-details" data-container-section="info" style="padding: 0px; margin: 16px 0px 8px;"><a data-test="journal-link" href="https://www.nature.com/ng" style="vertical-align: baseline; text-decoration-skip: objects; text-decoration: none; color: rgb(0, 102, 153);"><i data-test="journal-title" style="font-size: 23px;">Nature Genetics</i></a><span style="font-size: 1.6rem;"> </span><span data-test="journal-volume" style="font-size: 1.6rem;"><span class="u-visually-hidden" style="border: 0px; clip: rect(0px, 0px, 0px, 0px); height: 1px; margin: -592.359375px; overflow: hidden; padding: 0px; width: 1px; position: absolute !important;">volume</span><br></span><span class="u-visually-hidden" style="border: 0px; clip: rect(0px, 0px, 0px, 0px); height: 1px; margin: -592.359375px; overflow: hidden; padding: 0px; width: 1px; position: absolute !important;"><span style="font-size: 20px;">pa</span></span></p><div class="c-article-metrics-bar__wrapper u-clear-both" style="font-size: 1.6rem; margin: 0px; padding: 0px;"><ul class="c-article-metrics-bar u-list-inline" style="margin: 0px; display: flex; flex-wrap: wrap; line-height: 1.3; font-size: 1.6rem; list-style: none; padding: 0px;"><li class="c-article-metrics-bar__item" style="-webkit-box-align: baseline; align-items: baseline; border-right-width: 0px; margin-right: 8px; display: inline;"><p class="c-article-metrics-bar__details" style="padding: 0px; margin: 0px;"><a href="https://www.nature.com/articles/s41588-020-0610-9/metrics" data-track="click" data-track-action="view metrics" data-track-label="link" rel="nofollow" style="vertical-align: baseline; text-decoration-skip: objects; text-decoration: none; color: rgb(0, 102, 153);"><span class="u-visually-hidden" style="border: 0px; clip: rect(0px, 0px, 0px, 0px); height: 1px; margin: -592.359375px; overflow: hidden; padding: 0px; width: 1px; position: absolute !important;">details</span></a></p></li></ul></div></ul></div><div data-article-body="true" class="c-article-body" style="margin: 0px; padding: 0px; clear: both;"><section aria-labelledby="Abs1" lang="en"><div class="c-article-section" id="Abs1-section" style="margin: 0px; padding: 0px; clear: both;"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="Abs1" style="caret-color: rgb(34, 34, 34); color: rgb(34, 34, 34); font-family: Lora, Palatino, Times, "Times New Roman", serif; -webkit-text-size-adjust: 100%; padding: 0px 0px 8px; margin: 0px 0px 8px; border-bottom-width: 2px; border-bottom-style: solid; border-bottom-color: rgb(213, 213, 213); line-height: 1.24;"><span style="font-size: 22px;">Abstract</span></h2><div class="c-article-section__content" id="Abs1-content" style="margin: 0px 0px 40px; padding: 0px;"><p style="caret-color: rgb(34, 34, 34); color: rgb(34, 34, 34); font-family: Lora, Palatino, Times, "Times New Roman", serif; font-size: 18px; -webkit-text-size-adjust: 100%; padding: 0px; margin: 0px 0px 28px; word-wrap: break-word;">Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson's disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson's disease.....</p><p style="caret-color: rgb(34, 34, 34); color: rgb(34, 34, 34); font-family: Lora, Palatino, Times, "Times New Roman", serif; font-size: 18px; -webkit-text-size-adjust: 100%; padding: 0px; margin: 0px 0px 28px; word-wrap: break-word;"><span style="-webkit-text-size-adjust: auto; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: UICTFontTextStyleTallBody; font-size: 19px;"></span>For the rest of the article:</p><p style="padding: 0px; margin: 0px 0px 28px; word-wrap: break-word;"><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: UICTFontTextStyleTallBody; font-size: 19px; -webkit-text-size-adjust: auto;"><a href="https://www.nature.com/articles/s41588-020-0610-9" dir="ltr" x-apple-data-detectors="true" x-apple-data-detectors-type="link" x-apple-data-detectors-result="0" style="color: currentcolor;">https://www.nature.com/articles/s41588-020-0610-9</a></span><br style="-webkit-text-size-adjust: auto; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: UICTFontTextStyleTallBody; font-size: 19px;"><span style="-webkit-text-size-adjust: auto; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: UICTFontTextStyleTallBody; font-size: 19px;"></span><br style="-webkit-text-size-adjust: auto; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: UICTFontTextStyleTallBody; font-size: 19px;"></p></div></div></section></div></div></div></div>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-91375327821583910152020-06-08T00:24:00.001-07:002020-06-08T00:24:29.062-07:00Doctors treat Parkinson’s with a novel brain cell transplant - STAT<div dir="ltr"><br>https://www.statnews.com/2020/05/12/medical-first-parkinsons-brain-cell-transplant-stem-cells/</div><br>-bob<br><div dir="ltr"><span style="background-color: rgba(255, 255, 255, 0);">•••••••••••••••••••••••••••••••••••••••••••••<br>Bob Cowart<br>Email: <a href="mailto:bob@cowart.com">bob@cowart.com</a><br>Phone: <a href="tel:510-540-6667" x-apple-data-detectors="true" x-apple-data-detectors-type="telephone" x-apple-data-detectors-result="4/2">510-540-6667</a><br>Books: <a href="http://www.amazon.com/Robert-Cowart/e/B001HOJ3ZQ">http://www.amazon.com/Robert-Cowart/e/B001HOJ3ZQ</a><br>Blog: <a href="http://bobcowart.blogspot.com/">http://bobcowart.blogspot.com</a> <br>Twitter: @bobcowart</span></div>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-73121488577797396462020-06-01T09:29:00.001-07:002020-06-01T09:29:24.853-07:00A Common Cough Syrup Drug Just Passed Another Trial as Parkinson's Treatment<a href="https://www.sciencealert.com/drug-used-in-cough-syrup-for-decades-offers-new-hope-as-parkinson-s-treatment">https://www.sciencealert.com/drug-used-in-cough-syrup-for-decades-offers-new-hope-as-parkinson-s-treatment</a>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0tag:blogger.com,1999:blog-1782754671342094996.post-65463618151521004272020-05-26T12:28:00.001-07:002020-05-26T12:28:36.292-07:00Baking Soda Fights AutoImmune Disease | NaturalHealth365Interesting article about study showing that baking soda can lower inflammation.
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<br><a href="https://www.naturalhealth365.com/autoimmune-disease-baking-soda-3415.html">https://www.naturalhealth365.com/autoimmune-disease-baking-soda-3415.html</a>Bobhttp://www.blogger.com/profile/12662858203981295104noreply@blogger.com0