Saturday, June 14, 2014

DHEA, Testosterone and Parkinson's disease

This is a comment in the New York Times in response to an article about depression and Parkinson's. 

I suggest the common cause of the connection of depression with Parkinson's disease is low dehydroepiandrosterone (DHEA). DHEA is known to be low in depression.

Furthermore, I suggest Parkinson's disease is caused by a combination of low DHEA and testosterone. Low testosterone and DHEA would reduce gene activation and expose defective genes in Parkinson's disease. Being depressed would be a symptom of low DHEA. In individuals who also experience low testosterone and carry the malfunctioning gene, the incidence of Parkinson's disease would increase dramatically.

I invite you to read: "Parkinson's disease, DHEA, and Testosterone," at:'s DHEA Testosterone.htm 

and a detailed explanation of the interaction of testosterone and DHEA in gene activation and its consequences:  "DHEA, Estradiol, Testosterone, and the Relevance of Their Ratio …The Androgen Receptor …and the Secular Trend," at: Receptor and Secular Trend.htm

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