Friday, March 17, 2017

Global Lyme Alliance Doubles Funding Commitment for Lyme Disease

Global Lyme Alliance Doubles Funding Commitment for Lyme Disease 

Thu Mar 16, 2017 1:46 pm (PDT) . Posted by: 

"Rick Laferriere" ri_lymeinfo 

Global Lyme Alliance Doubles Funding Commitment for Lyme Disease Research 

GLA Awards Record $2 Million in 2016-2017 Grants to Top Researchers Throughout the U.S. 

February 7, 2017 
https://globallymealliance.org/press-releases/global-lyme-alliance-doubles-funding-commitment-for-lyme-disease-research/ https://globallymealliance.org/press-releases/global-lyme-alliance-doubles-funding-commitment-for-lyme-disease-research/ 
or http://tinyurl.com/hxl9w4s 

Global Lyme Alliance https://globallymealliance.org/ 
222 Railroad Ave. #2B 
Greenwich, Connecticut 06830 

Global Lyme Alliance (GLA), the leading private nonprofit dedicated to conquering Lyme disease through research and education, announced today that it is awarding a record total of approximately $2 million in grants to top researchers at leading academic and medical research institutions across the U.S. These recipients of GLA's 2016-2017 grant cycle are working on a wide array of projects to develop a greater understanding of the disease, improve diagnostics, treatment and prevention. 

"For years our organization has led the Lyme community in identifying and backing innovative research, so we're especially proud and excited that we've doubled our research funding since last year," said Scott Santarella, GLA's CEO. "The more funds we raise, the faster we can solve the mystery of Lyme disease and bring about change for millions who suffer from tick-borne illnesses." 

"GLA prides itself for providing the vision to drive the research agenda, initiating the teaming of top researchers to collaborate on projects and evaluating research proposals received globally. We continue to provide the leadership in scientific research that others follow and build upon," said GLA Chairman and Scientific Advisory Board member Robert Kobre. 

In announcing the new grants, Santarella noted that GLA had received the most grant applications in its history—$4.3 million in funding requests. 

"While we were pleased to receive so many quality grant applications this year, such a profusion underscores the fact that there are far more talented scientists eager to focus on Lyme disease than there is funding to support them," Santarella said. He noted, for example, that $25 million is allocated by the National Institutes of Health annually for Lyme research, which infects more than 330,000 in the U.S. each year, compared with $42 million for the mosquito-transmitted West Nile virus, which affected about 2,000 in the U.S. last year. 

"Federal funding for Lyme research is miniscule, yet the Lyme threat keeps growing," he said. "This speaks to GLA's importance in working with private donors to fill the void and drive advancements in the field." 

GLA's 2016-2017 grants were awarded to researchers at the following institutions: Columbia University; Cornell University; Institute for Systems Biology; Johns Hopkins University; Northeastern University; State University of New York-Stony Brook; Tulane National Primate Research Center; University of California-Davis; University of California-San Francisco; University of Illinois-Chicago; University of North Dakota; University of Pennsylvania, and University of Texas-San Antonio. 

"As the number of Lyme and tick-borne disease cases continues to grow, there is a tremendous impetus to keep the science moving forward," said Mayla Hsu, Ph.D., GLA's Director of Research and Science. "GLA is proud to support the important research being conducted by some of the best and brightest men and women in the field today." 

GLA's research portfolio includes a broad range of projects such as persistence of infection after antibiotic treatment and the development of new diagnostics. Studies focus on microbial physiology; genetic work to determine how the bacteria that causes Lyme survives in a host; efficacy of different modes of antibiotic therapy, and why some people continue to have symptoms despite the seeming absence of bacteria. 

Researchers were selected following a rigorous evaluation process using guidelines established by the National Institutes of Health (NIH). Each proposal was evaluated by Grant Review Committee members of GLA's Scientific Advisory Board and met the same scientific standards that NIH applies to its own grant review process. The resulting 2016-2017 grant awards represent projects judged to have exceptional prospects of delivering measurable advances. 

Lyme disease is the most common vector-borne disease in the U.S. There are no accurate diagnostic tests for the disease, no tests to prove that Lyme bacteria are eradicated or that an individual is cured. Some 20 percent of individuals with Lyme end up with long-term health problems. 

ABOUT GLOBAL LYME ALLIANCE 
Global Lyme Alliance is a leading private nonprofit dedicated to conquering Lyme and other tick-borne diseases through research and education. The 501(c)(3) nonprofit is headquartered in Greenwich, CT. For more information go to GLA.org http://globallyme.wpengine.com/
Press Release Source: http://tinyurl.com/hxl9w4s http://tinyurl.com/hxl9w4s 

New technique for killing ticks on your property

Ticks: If You Can't Beat 'Em, Douse Their Animal Hosts in Insecticide 
Entomology Today, Entomological Society of America, Annapolis, Maryland 

March 16, 2017 
https://entomologytoday.org/2017/03/16/ticks-if-you-cant-beat-em-douse-their-animal-hosts-in-insecticide/ https://entomologytoday.org/2017/03/16/ticks-if-you-cant-beat-em-douse-their-animal-hosts-in-insecticide/ 
or http://tinyurl.com/jc4z5rq http://tinyurl.com/jc4z5rq 

An emerging tool in the fight against tick-borne disease, host-targeted bait boxes employ a sneaky trick: turning some of ticks' favorite carriers —small mammals like mice and chipmunks —against them. And a new study in Journal of Medical Entomology https://academic.oup.com/jme/article/3070958/Evaluation-of-the-SELECT-Tick-Control-System-TCS-ashows an improved design has made such bait boxes an increasingly viable addition to integrated tick management practices. 

Mice, chipmunks, and other small mammals are common hosts for the blacklegged tick (Ixodes scapularis), providing the ticks a home, food source, and means of spreading, all in one. Host-targeted bait boxes take the common rodent bait box design and add an extra element: a cloth wick soaked in tick-killing insecticide that the animal must contact on its way in and out of the box. Ticks that subsequently attach to the animal die after exposure to the insecticide. 

Such bait boxes have been in production since 2002, but early designs left them prone to damage by squirrels and other large animals. In 2012, a new version, the SELECT Tick Control System (TCS) was introduced by Tick Box Technology Corporation (Norwalk, Conn.), featuring a two-piece metal cover to prevent such damage. That improvement appears to have greatly increased their viability, according to researchers at the Centers for Disease Control and Prevention and the Tick-borne Diseases Program in Monmouth County, New Jersey, who helped test the SELECT TCS boxes. 

Their study, published today in the Journal of Medical Entomology https://academic.oup.com/jme/article/3070958/Evaluation-of-the-SELECT-Tick-Control-System-TCS-a, shows that the host-targeted tick control boxes significantly reduced the prevalence of ticks on residential properties where they were deployed. After four nine-week deployments, two each conducted in 2012 and 2013, tick abundance was reduced 97 percent in 2014 on treated properties. 

"These results demonstrate that SELECT TCS may provide a significant reduction in exposure to host-seeking ticks, while reducing the use of pesticide compared with traditional area-wide chemical control," the authors of the study write. 

The researchers deployed the bait boxes on 12 residential, woodland-adjacent properties in Ocean and Monmouth counties in New Jersey in 2012 and 10 properties in 2013. After placing the boxes, they returned periodically to measure whether and how many of the boxes had been visited by animals. Before and after the test periods, they also trapped mice and chipmunks to measure their tick infestations, on both the treated properties and on untreated land for comparison. The researchers also collected tick samples on the treated and untreated properties, before and after deployment of the bait boxes, to measure tick prevalence. 

Because host-targeted bait boxes affect ticks in their larval and nymphal life stages, the method takes longer to affect tick populations than other management methods, the researchers note. And they also suggest further research is needed to measure the optimal density of boxes and their specific effect on the prevalence of disease such as Lyme and babesiosis in ticks and hosts. 

But, the results of this study are promising, the study concludes. "SELECT TCS appears to offer an effective alternative, delayed efficacy notwithstanding, to the use of area application of acaricide in residential situations." 

Entomological Society of America 
3 Park Place, Suite 307 
Annapolis, MD 21401-3722 
Press release source: http://tinyurl.com/jc4z5rq http://tinyurl.com/jc4z5rq 

Monday, March 13, 2017

Microbe-Microbe and Host-Microbe Interactions Drive Microbiome Dysbiosis and Inflammatory Processes


An extensive microbiome comprised of bacteria, viruses, bacteriophages, and fungi is now understood to persist in nearly every human body site, including tissue and blood. The genomes of these microbes continually interact with the human genome in order to regulate .

Electrocardiographic progression of acute Lyme disease

QUOTE-  "This is the first case in the literature that has captured the electrocardiographic evolution of Lyme carditis, day by day until complete resolution."

 2017 Mar 1. pii: S0735-6757(17)30165-1. doi: 10.1016/j.ajem.2017.02.052. [Epub ahead of print]

Electrocardiographic progression of acute Lyme disease.

Author information

1
Heart Rhythm Service, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada.
2
Heart Rhythm Service, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada. Electronic address: barancha@kgh.kari.net.

Abstract

Lyme carditis poses a challenge to physicians given dramatic clinical presentations like the one presented in this case. 
Quite frequently, these young patients are implanted with permanent pacemakers; given lack of knowledge on the transient nature of the cardiac conduction system inflammation. 
This is the first case in the literature that has captured the electrocardiographic evolution of Lyme carditis, day by day until complete resolution.
Copyright © 2017 Elsevier Inc. All rights reserved.
PMID:
 
28279540
 
DOI:
 
10.1016/j.ajem.2017.02.052

Friday, March 10, 2017

Legal precedent for SSDI being awarded for ILADS-diagnosed Lyme patients

TOUCHED BY LYME: Lyme disability ruling is a positive step

image_print

Barbara Arnold, an attorney in Oakland, California, specializes in helping people get Social Security Disability Insurance (SSDI) benefits after Lyme and related diseases force them out of their jobs. She has personal experience with chronic Lyme disease, being a patient herself, and having volunteered for years as a Lyme patient support group leader. She has also testified before state and municipal government officials about the needs of people with tick-borne illness.

Recently, Ms. Arnold's work in representing a Lyme patient plaintiff before the U.S. District Court for the Northern District of California has led to a court order recognizing that chronic Lyme disease can provide a legal basis for a claim for federal disability benefits.

See the rest of the story, and important links to cases:


Sunday, March 5, 2017

Wearable Sensors Spot Lyme Disease - IEEE Spectrum

Wearable Sensors Spot Lyme Disease


http://spectrum.ieee.org/view-from-the-valley/consumer-electronics/portable-devices/wearable-sensors-spot-lyme-disease


Bob C.

•••••••••••••••••••••••••••••••••••••••••••••
Bob Cowart
Email: bob@cowart.com
Phone: 510-540-6667
Books: http://www.amazon.com/Robert-Cowart/e/B001HOJ3ZQ
Blog: http://bobcowart.blogspot.com 
Facebook: bcowart1
Twitter: @bobcowart




Monday, February 27, 2017

Rabbit ticks? Widely found in the Americas


Notice a rabbit tick was found in Nantucket, but can also be found from Alaska to Argentina.

Haemaphysalis leporispalustris, the rabbit tick (occasionally known as the grouse tick), is a species of tick that is widely distributed in the Americas, stretching from Alaska to Argentina. H. leporispalustris is known to have one of the largest distributions for a tick originating in the New World. 

Strains of Rickettsia rickettsii, the disease aften of Rocky Mountain spotted fever have been found in the rabbit tick. Evidence of this bacteria in rabbit ticks have been found in countries such as Costa Rica and Argentina. A Brazilian strain of the Rickettsia rickettsii was also found recently in Rio de Janeiro in ticks found on wild rabbits as well as rabbit ticks in Costa Rica. 

Since rabbit ticks support the infection of virulent strains of this bacteria, H. leporispalustris contains a role in the maintenance of R. rickettsii in the Americas. H. leporispalustris is currently one of the known vectors that is keeping this bacteria in circulation. 

Also, H. leporispalustris transmits Coxiella burnetii and Francisella tularensis.[10] Strains of Anaplasma bovis have also been found in rabbit ticks, which was discovered in a Nantucket tick study of the bacteria.






Source for info- WIKI




Gut microbes and mental health: A review

"Perturbations of the gut microbial community have already been implicated in multiple host diseases such as obesity, diabetes, and inflammation, while recent evidence suggests a potential role of the microbiota-gut-brain axis in neuropsychiatric disorders, such as depression and anxiety."

 2017 Jan 25. pii: S0889-1591(17)30016-8. doi: 10.1016/j.bbi.2017.01.016. [Epub ahead of print]

Microbes and mental health: A review.

Author information

  • 1Department of Biochemistry and Microbiology, New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, NJ 08901, USA.
  • 2Department of Kinesiology and Health, Rutgers University, New Brunswick, NJ 08901, USA; The Rutgers Center for Lipid Research, New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, NJ 08901, USA; The Center for Digestive Health, New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, NJ 08901, USA.
  • 3Department of Kinesiology and Health, Rutgers University, New Brunswick, NJ 08901, USA.
  • 4Department of Kinesiology and Health, Rutgers University, New Brunswick, NJ 08901, USA; The Rutgers Center for Lipid Research, New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, NJ 08901, USA; The Center for Digestive Health, New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, NJ 08901, USA. Electronic address: saracamp@rci.rutgers.edu.

Abstract

There is a growing emphasis on the relationship between the microorganisms inhabiting the gut (gastrointestinal microbiota) and human health. 
The emergence of a microbiota-gut-brain axis to describe the complex networks and relationship between the gastrointestinal microbiota and host reflects the major influence this environment may have in brain health and disorders of the central nervous system (CNS). 
Bidirectional communication between the microbiota and the CNS occurs through autonomic, neuroendocrine, enteric, and immune system pathways. 
Potential neurobiological mechanisms through which disruptions in this network may impact health and disease include hypothalamic-pituitary-adrenal (HPA)-axis activation, and altered activity of neurotransmitter and immune systems. 
Perturbations of the gut microbial community have already been implicated in multiple host diseases such as obesity, diabetes, and inflammation, while recent evidence suggests a potential role of the microbiota-gut-brain axis in neuropsychiatric disorders, such as depression and anxiety. 
Here, we review the current literature related to the influence of the gut microbial community on central nervous system function, with a specific focus on anxiety and depressive symptoms. 
The role of stress and stress-mediated changes in autonomic, neuroendocrine, immune, and neurotransmitter systems are examined, followed by a discussion of the role of the microbiota in novel gastrointestinal-based treatment options for the prevention and treatment of brain-based disorders such as anxiety and depression.
Copyright © 2017. Published by Elsevier Inc.

KEYWORDS: 

Anxiety; Depression; HPA-axis; Microbiome; Microbiota-gut-brain axis
PMID:
 
28131791
  
DOI:
 
10.1016/j.bbi.2017.01.016
[PubMed - as supplied by publisher] 

Sunday, February 26, 2017

New Tests for B. miyamotoi & other pathogens in New York

This could be a HUGE step forward in Lyme diagnosis and treatment!

-Bob
 2017 Mar;8(3):407-411. doi: 10.1016/j.ttbdis.2017.01.004. Epub 2017 Jan 16.

Detection of Borrelia miyamotoi and other tick-borne pathogens in human clinical specimens and Ixodes scapularis ticks in New York State, 2012-2015.

Author information

  • 1Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY 12208, United States. Electronic address: danielle.wroblewski@health.ny.gov.
  • 2Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY 12208, United States.
  • 3Vector Ecology Laboratory, Bureau of Communicable Disease Control, New York State Department of Health, Empire State Plaza C456-C467B, Albany, NY 12237, United States.

Abstract

Borrelia miyamotoi (Bm) is a recently emerging bacterial agent transmitted by several species of ixodid ticks. Diagnosis of Bm infection can be challenging, as the organism is not easily cultivable. 
We have developed and validated a multiplex real-time PCR to simultaneously identify Bm infection and the agents causing human granulocytic anaplasmosis and human monocytic ehrlichiosis, Anaplasma phagocytophilum and Ehrlichia chaffeensis, respectively. 
The assay is 100% specific; highly sensitive, detecting 11 gene copies of Bm DNA in both whole blood and cerebral spinal fluid; and provides rapid results in less than two hours. 
A retrospective study of 796 clinical specimens collected between the years 2012 and 2014 and a prospective study of 366 clinical specimens were performed utilizing this novel assay to evaluate the frequency of Bm infection in New York State (NYS). 
Eight clinical specimens (1%) were found to be positive for Bm, 216 were positive for A. phagocytophilum, and 10 were positive for E. chaffeensis. 
Additionally, we tested 411 I. scapularis ticks collected in NYS during 2013 and 2014 in a separate multiplex real-time PCR to determine the prevalence of Bm, A. phagocytophilum, Borrelia burgdorferi s.s., and Borrelia species. 
Our results indicated rates of 1.5%, 27%, 19.7%, and 8.8% respectively. The ability to monitor both the frequency and geographic distribution of Bm cases and the prevalence and geographic distribution of Bm in ticks will help create a better understanding of this emerging tick-borne pathogen.
Published by Elsevier GmbH.

KEYWORDS: 

Borrelia miyamotoi; Ixodes scapularis; Multiplex; Real-time PCR; Tick-borne disease
PMID:
 
28131594
 
DOI:
 
10.1016/j.ttbdis.2017.01.004
[PubMed - in process]
Link here

Tuesday, February 21, 2017

Targeting Gut Bacteria May Be The Key To Preventing Alzheimer's |

The Huffington Post


I see more and more articles about diseases, including Parkinson's, having a relationship to diet. Or more specifically, having a relationship with the gut microbiome. Here is yet another one. 

Bob