Sunday, March 23, 2014

What ticks do under your skin....

What ticks do under your skin: two-photon intravital 
imaging of ixodes scapularis feeding in the presence of the 
lyme disease spirochete. 

Bockenstedt LK, Gonzalez D, Mao J, Li M, Belperron AA, 
Haberman A.
/Yale Journal of Biology and Medicine/, 2014 Mar 
5;87(1):3-13. eCollection 2014.


Abstract

Lyme disease, due to infection with the Ixodes-tick 
transmitted spirochete /Borrelia burgdorferi/, is the most 
common tick-transmitted disease in the northern hemisphere.

Our understanding of the tick-pathogen-vertebrate host 
interactions that sustain an enzootic cycle for /B. 
burgdorferi/ is incomplete.

In this article, we describe a method for imaging the 
feeding of /Ixodes scapularis/ nymphs in real-time using 
two-photon intravital microscopy and show how this 
technology can be applied to view the response of Lyme 
borrelia in the skin of an infected host to tick feeding.

Free, full text including images and supplementary movies:

No comments:

Post a Comment

Please be constructive in your comments.