Dangerous Antibiotic-Resistance Gene Identified in China

NEJM Journal Watch 

http://www.jwatch.org/fw110874/2015/11/18/dangerous-antibiotic-resistance-gene-identified-china?query=pfwRS&jwd=000013533191&jspc=
Medical News | 

Physician's First Watch

November 18, 2015

Dangerous Antibiotic-Resistance Gene Identified in China — Implications "Enormous"

By Joe Elia

Edited by Susan Sadoughi, MD, and Richard Saitz, MD, MPH, FACP, FASAM

Polymyxin resistance, possibly caused by extensive use of colistin in meat production, has emerged in China, according to a study in the Lancet Infectious Diseases.

The resistance factor, called MCR-1, is carried on a plasmid (a small, extrachromosomal piece of DNA in bacteria) and could be transferred between strains of E. coli. It has also occurred in other enterobacteria, including Klebsiella and Pseudomonas.

Samples of meat sold at retail in China showed an increased prevalence of the factor between 2011 and 2014. Sixteen hospitalized people also tested positive for MCR-1.

Commentators say that "the implications of this finding are enormous," warning that MCR-1 "will seriously limit the lifespan of the polymyxins as the backbone of regimens against multiply resistant Gram-negative bacilli."

Link(s):

Lancet Infectious Diseases article (Free abstract)

Lancet Infectious Diseases comment (Subscription required)

Background: NEJM Journal Watch Infectious Diseases coverage of increasing colistin use (Your NEJM Journal Watch registration required)

- See more at: http://www.jwatch.org/fw110874/2015/11/18/dangerous-antibiotic-resistance-gene-identified-china?query=pfwRS&jwd=000013533191&jspc=#sthash.fUlrnXWt.dpuf

http://www.thelancet.com/journals/laninf/article/PIIS1473-3099%2815%2900424-7/abstract

"Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study"

Scientific evidence for persistence of Lyme bacteria

The list of scientific references from ILADS, with information provided by Dr. Bransfield, is actually 5 separate lists. 

The first list (general) is very long. Farther down are separate lists: Another long one on psychiatric topics, and toward the bottom of the file, lists on AD, autism, and congenital transmission.  

Thanks to MMI (Microbes and Mental Illness) for having posted these lists, and to Dr. Bransfield for his dedicated work on them. 

http://www.ilads.org/ilads_news/wp-content/uploads/2015/09/EvidenceofPersistence-V2.pdf

New movie about the Lyme controversy

This is a recent video by Randy Sykes about the Lyme controversy:

 

https://www.youtube.com/watch?v=ow53uy1qElI

 

Fossilized tick found in amber indicates Lyme disease is older than human race

Tick larvae encased in a 15- to 20-million-year-old piece of amber contains oldest known ancestor of Borrelia burgdorferi.

Mar 09, 2015

Veterinary professionals are no strangers to the stealthy spirochete Borrelia burgdorferi—but the discovery of spirochete-like cells in a 15-million-year-old amber-encased tick reveals that the bacteria have been lurking around long before humans walked the Earth.

The discovery was made by George Poinar Jr., a paleoentomologist, parasitologist and one of the world's leading experts on plant and animal life forms found preserved in amber. In fact, you may remember the amber-encased mosquito in the plot of the wildly popular Michael Crichton novel and movie Jurassic Park. Poinar's early research is said to have inspired the story.

Read the whole story:

http://veterinarynews.dvm360.com/fossilized-tick-indicates-lyme-disease-older-human-race

Your data can help find a cure for Lyme

Invites You To Participate in MyLymeData MyLymeData is a patient-powered research project. It was conceived by patients, is run by patients, and addresses the issues that patients care about. It lets Lyme disease patients learn from each other and provides data that can help drive research to improve their lives. Together we can find a cure for Lyme disease! VISIT US AT LYMEDISEASE.ORG/MYLYMEDATA Email: mylymedata@lymedisease.org Help us spread the word about MyLymeData Email not displaying correctly? View it in your browser. Forward email LymeDisease.org | PO Box 1352 | Chico | CA | 95927

Malaria code cracked?

http://www.bbc.com/news/health-34808267

[Scientists] say it is down to protein molecules called cyclins that cause cells to divide rapidly in the malaria parasite. Since Malaria and Babesiosis have common traits, I post this article. Both are treated with the same meds, typically: Mepron and Malarone.

http://mail.mentalhealthandillness.com/mailman/listinfo/mmi_mentalhealthandillness.com

Is Alzheimer’s Disease Infectious?

AIMS Neuroscience, Volume 2 (4): 240–258. DOI: 10.3934/Neuroscience.2015.4.240 Received date 31 July 2015, Accepted date 4 November 2015, Published date 11 November 2015

Abstract: Alzheimer's disease (AD) has been recently considered as a possible brain infection related to the Creutzfeldt-Jakob disease (CJD) transmissible dementia model. As with CJD, there is controversy whether the infectious agent is an amyloid protein (prion theory) or a bacterium. In this review, we show that the prion theory lacks credibility because spiroplasma, a tiny wall-less bacterium, is clearly involved in the pathogenesis of CJD and the prion amyloid can be separated from infectivity. In addition to prion amyloid deposits, the transmissible agent of CJD is associated with amyloids (A-β, Tau, and α-synuclein) characteristic of other neurodegenerative diseases including AD and Parkinsonism. Reports of spiroplasma inducing formation of α-synuclein in tissue culture and Borrelia spirochetes inducing formation of A-β and Tau in tissue culture suggests that bacteria may have a role in the pathogenesis of the neurodegenerative diseases.

literature review on persistence

Here is a literature review on persistence of Lyme bacteria post antibiotic therapy. 

Review of evidence for immune evasion and persistent infection in Lyme disease. - PubMed - NCBI

				Review of evidence for immune evasion and persistent inf... Int J Gen Med. 2013 Apr 23;6:291-306. doi: 10.2147/IJGM.S44114. Print 2013.

PANS - A case for antibiotic therapy?

A PANS Case Study, Immune Treatment Reduced Psychiatric Symptoms

(Robert M. Post)

 

http://bipolarnews.org/?p=3446#more-3446

 

"Pediatric acute neuropsychiatric syndrome (PANS) is a little-known syndrome in which a child has an acute onset of psychiatric symptoms following a bacterial or viral infection, when the antibodies generated to fight the infection instead attack neurons in the brain. The behavioral alterations can be severe and resistant to the usual psychotropic drug treatments. PANS often requires antibiotics and immune-targeted therapies."

 

"Mycoplasma pneumonia, influenza, Epstein Barr virus, and Borrelia burgdorferi (Lyme disease) are often involved."

 

 

Ultimate cause of Alzheimer's may be fungal, cadaver study suggests

Ultimate cause of Alzheimer's may be fungal, cadaver study suggests.

The Economist (10/23/15) reports that a study published online Oct. 15 in the journal Scientific Reports suggests that "the ultimate cause of Alzheimer's is fungal." Researchers arrived at this conclusion after examining "brain tissue from 25 cadavers, 14 of which belonged to people who had had Alzheimer's disease when alive." The study authors now "think a clinical trial of anti-fungal drugs is the next logical step."
 

Robert C Bransfield, MD, DLFAPA

Alzheimer's patients have high levels of ceramides, lipid rafts comprised of very long chain fatty acids.
Mattson published this initially in an NIH study in 2004  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC357053/ and
  again in 2010  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907186/ 
Alzheimer's does not originate in the brain as once thought, it is a peroxisomal disorder induced by toxic insult turning on cytokines and
 disabling / inhibiting the ability to beta oxidize (burn) very long chain fatty acids.
Spirochetes feed on very long chain fatty acids, in fact, lyme cannot survive without very long chain fatty acid food source
  because they cannot form them.  The base of the flagellum consists of these very long chain fatty acids.  The flagellum
 swings like a wrecking ball (Edward Kane, age 90, description of the phenomenon) and is nonfunctional without these
 specialized very long chain fatty acids it feeds on from its host.
Toxic mold exposure results in  DNA adducts (epigenetic) insult, cytokine expression, major inhibition of beta oxidation, and a sharp rise in 
   very long chain fatty acids.
Its not just in Alzheimers...also psychiatric disorders, metabolic abnormalities, Autism, Parkinson's, ALS, MS, Post Stroke, NeuroLyme, CFS....

Explains also why they do so well with phenylbutyrate. potent anti-fungal.

Easy to treat.  Who paid attention to my previous writings....

Dr. Patricia Kane, PhD, Director
NeuroLipid Research Foundation