Sunday, March 23, 2014

What ticks do under your skin....

What ticks do under your skin: two-photon intravital 
imaging of ixodes scapularis feeding in the presence of the 
lyme disease spirochete. 

Bockenstedt LK, Gonzalez D, Mao J, Li M, Belperron AA, 
Haberman A.
/Yale Journal of Biology and Medicine/, 2014 Mar 
5;87(1):3-13. eCollection 2014.


Lyme disease, due to infection with the Ixodes-tick 
transmitted spirochete /Borrelia burgdorferi/, is the most 
common tick-transmitted disease in the northern hemisphere.

Our understanding of the tick-pathogen-vertebrate host 
interactions that sustain an enzootic cycle for /B. 
burgdorferi/ is incomplete.

In this article, we describe a method for imaging the 
feeding of /Ixodes scapularis/ nymphs in real-time using 
two-photon intravital microscopy and show how this 
technology can be applied to view the response of Lyme 
borrelia in the skin of an infected host to tick feeding.

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