Genetic insights into the etiology of Parkinson’s disease

Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease

• Julien Bryois, 
• Nathan G. Skene, 
• Thomas Folkmann Hansen, 
• Lisette J. A. Kogelman, 
• Hunna J. Watson, 
• Zijing Liu, 
• Eating Disorders Working Group of the Psychiatric Genomics Consortium, 
• International Headache Genetics Consortium, 
• 23andMe Research Team, 
• Leo Brueggeman, 
• Gerome Breen, 
• Cynthia M. Bulik, 
• Ernest Arenas, 
• Jens Hjerling-Leffler & 
• Patrick F. Sullivan 

Nature Genetics volume
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• details

Abstract

Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson's disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson's disease.....

For the rest of the article:

https://www.nature.com/articles/s41588-020-0610-9

Doctors treat Parkinson’s with a novel brain cell transplant - STAT

https://www.statnews.com/2020/05/12/medical-first-parkinsons-brain-cell-transplant-stem-cells/

-bob

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Bob Cowart
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A Common Cough Syrup Drug Just Passed Another Trial as Parkinson's Treatment

https://www.sciencealert.com/drug-used-in-cough-syrup-for-decades-offers-new-hope-as-parkinson-s-treatment

Baking Soda Fights AutoImmune Disease | NaturalHealth365

Interesting article about study showing that baking soda can lower inflammation.

https://www.naturalhealth365.com/autoimmune-disease-baking-soda-3415.html

A Clinical Diagnostic System for Late-Stage Neuro Lyme Borreliosis

A Clinical Diagnostic System for Late-Stage Neuropsychiatric Lyme Borreliosis Based upon an Analysis of 100 Patients

A study by the respected researcher Robert Bransfield and three others. 

Healthcare | Free Full-Text | 

https://www.mdpi.com/2227-9032/8/1/13

The Sounds of Science

Maybe you've seen this before but it applies more with each passing day...

KosAbility: Parkinson's and Pesticides

Good article about the relationship between pesticides and Parkinson's disease.

https://www.dailykos.com/story/2016/9/25/1574133/-KosAbility-Parkinson-s-and-Pesticides

-Bob

Mold, Air, Water, Sewage testing company

I've been looking for a company who can test air quality inside and outside of my house. I have wondered foe years whether my house's inside air was polluted, because in the AM when I awake, I often feel poisoned. I've looked into oxygen deprivation (which would cause CO2 poisoning) and mold, so far. I used Real Time labs for mold and micotoxin testing. I've treated my house and cars for micotoxins with chlorine dixoide gas. I still don't think I have found the culprit, but I suspect it has to do with gut dysbiosis more than with the external environment, though both may play a part.  In any case, the testing that these folks do might be among my next areas of inquiry.  -Bob Why Test for Sewage Contamination? Exposure to sewage contamination increases the risk of contracting diseases of the digestive system and other related illnesses. Potential disease causing organisms in sewage contamination include E. coli (some strains), Salmonella, and Shigella. Sewage contamination can come from flooding events, failing septic systems, wastewater treatment plants, sewer overflows, vessel sewer discharge, runoff from surfaces, livestock, pets, wildlife, and humans.  The following bacteria are used as indicators of sewage contamination. E. coli Total coliforms Fecal coliforms Enterococci Fecal Streptococcus. These bacteria are not a health threat themselves but their presence is used as an indication of other potentially harmful bacteria. Learn More... General Bacteria Testing Bacteria Testing We perform various bacterial analytical tests at Mold & Bacteria Consulting Laboratories (MBL). We can test air samples (taken by an RCS sampler or an Anderson sampler), surface samples (taken by culture-swabs), and water samples, as well as many other types of samples. If you have a question regarding a particular test (including those not listed here), please ... Continue Reading Online... MBL Among The CDC ELITE Certified Labs in Legionella Testing Mold & Bacteria Consulting Laboratories (MBL)  has certification in the analysis of Legionella bacteria by the prestigious Environmental Legionella Isolation Techniques Evaluation (ELITE) program of the US Centers for Diseases Control and Prevention (CDC). MBL is one of the only 3 Canadian independent laboratories having this industry-leading certification. MBL is also accredited by the Canadian Association For Laboratory Accreditation (CALA) ... Continue Reading Online... Online Mold Inspection, Identification and Control Course Our online mold training course is designed for people with busy schedules. The course is available 24/7 and can be taken in office or at home at any time of the day. Click Online Mold Training Course for more details. Happy to help. If you have any questions regarding mold or bacteria laboratory testing, please contact us at 905-290-9101 or send an email to info@moldbacteria.com Copyright © 2020 Mold & Bacteria Consulting Laboratories, All rights reserved.  You are receiving this email because you opted in at our website or Facebook page  Our mailing address is:  Mold & Bacteria Consulting Laboratories 1020 Brevik Place Unit 1A Mississauga, Ontario  L4W 4N7 Canada Add us to your address book Want to change how you receive these emails? You can update your preferences or unsubscribe from this list

Microdose lithium formulation is capable of halting signs of advanced Alzheimer’s and improving cognition, reducing anxiety

Interesting and useful article about using Lithium orotate for anxiety treatment. Dosing, etc.

https://www.everywomanover29.com/blog/microdose-lithium-formulation-is-capable-of-halting-signs-of-advanced-alzheimers-and-improving-

Stomach bacteria may slow - and even reverse - Parkinson's disease

Stomach bacteria may slow - and even reverse - Parkinson's disease

The study is published in Cell Reports.

Study Finds
Sat, 18 Jan 2020 00:01 UTC

© tutul_1410/stock.adobe.com
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Parkinson's disease, a progressive nervous system disorder that greatly affects movement, can have a detrimental impact on one's quality of life. While there are medications available that help control its symptoms, there is no known cure for the disease. However, researchers from the Universities of Edinburgh and Dundee in Scotland recently identified a potential game changer in the fight against Parkinson's. A common probiotic, or "good" bacteria, found in our stomachs that helps maintain digestive health appears to be able to slow, and even reverse, the accumulation of a protein known to be associated with Parkinson's. 

The groundwork for these findings were put in place by prior research that had identified a connection between brain function and gut bacteria. Now, using a group of roundworms, this study has discovered that the probiotic called Bacillus subtilis is capable of stopping the formation of toxic clumps in the brain that impede the flow of dopamine. Dopamine, besides its other uses, is integral to coordinating movement. 

Within the brains of Parkinson's patients, the protein known as alpha-synuclein builds up, forming these aforementioned toxic clumps. These clumps then cause the death of nerve cells that should be producing dopamine. It's the loss of these very cells that cause the trademark symptoms of Parkinson's, such as shaking or overall slowness of movement. 

The research team used a genetically altered group of roundworms capable of producing the human version of clump-forming alpha-synuclein. These worms were fed a variety of different over-the-counter probiotics, in an effort to see if any of them influenced subsequent clump formation. 

The results of the experiment revealed that Bacillus subtilis had a robust protective effect that prevented the buildup of the alpha-synuclein protein. The probiotic even was able to do away with some pre-existing clumps that had already formed within the worms. After being given Bacillus subtilis, the worms movements immediately improved. 

"The results provide an opportunity to investigate how changing the bacteria that make up our gut microbiome affects Parkinson's. The next steps are to confirm these results in mice, followed by fast-tracked clinical trials since the probiotic we tested is already commercially available," says Lead researcher Dr. Maria Doitsidou, of the Centre for Discovery Brain Sciences at the University of Edinburgh, in a release. 

This piece of research is just the latest in a string of studies over the past few years indicating that the gut microbiome residing in each one our stomachs plays a critical role in brain function. 

"Parkinson's is the fastest growing neurological condition in the world. Currently there is no treatment that can slow, reverse or protect someone from its progression but by funding projects like this, we're bringing forward the day when there will be," comments Dr Beckie Port, Research Manager at Parkinson's UK. "Changes in the microorganisms in the gut are believed to play a role in the initiation of Parkinson's in some cases and are linked to certain symptoms, that's why there is ongoing research into gut health and probiotics. 

"The results from this study are exciting as they show a link between bacteria in the gut and the protein at the heart of Parkinson's, alpha synuclein. Studies that identify bacteria that are beneficial in Parkinson's have the potential to not only improve symptoms but could even protect people from developing the condition in the first place," she concludes. 

The study is published in Cell Reports.

Comment: See also:

Parkinson's, Alzheimer's, and the new science of hope
Appendix removal correlated with higher risk of Parkinson's
Treating Parkinson's with electrical spinal implant 'transforms lives'
Scientists discover mounting evidence that Parkinson's starts in the gut - not the brain
Smell of skin could lead to early diagnosis for Parkinson's
The appendix implicated in Parkinson's disease
Risk of Parkinson's disease increases with statin or 'cholesterol-lowering' drug use
Parkinson's disease may be triggered by virus that kills 'good bacteria' in the gut