Tracking Lyme Disease in Dogs May Help Protect Humans - Yahoo! News

Interesting means of determining estimated danger of infection in your region.

http://news.yahoo.com/tracking-lyme-disease-dogs-may-help-protect-humans-160807893.html

Antibodies Linked to Long-term Lyme Symptoms

Antibodies Linked to Long-term Lyme Symptoms

from Nature News

Some patients with Lyme disease still show symptoms long after their treatment has finished. Now proteins have been discovered that set these people apart from those who are easily cured.

People who experience the symptoms of Lyme disease, which include fatigue, soreness and memory or concentration loss, after treatment for the disorder are sometimes diagnosed as having chronic Lyme disease or post-Lyme disease syndrome. But these diagnoses are difficult to make, because the individuals no longer seem to harbour the bacteria that cause Lyme disease. And the symptoms could instead be indicative of chronic fatigue syndrome or depression.

Now Armin Alaedini at Weill Cornell Medical College in New York and his colleagues have found that patients diagnosed with post-Lyme disease syndrome have antibodies that suggest they carried the infection for an unusually long time. The finding, published in Clinical Immunology, might help the syndrome to be better understood, diagnosed and treated.

http://ow.ly/5XEON

5 Myths about Lyme Disease Treatment

Here's a very good pamphlet about Lyme disease. A good primer. It's from the Haverford Wellness Center. Oddly enough, it's in Havertown, PA, just across the street from the house I grew up in. I am tempted to go there the next time I get back east.
http://www.lyme-disease-testing.com/5-myths-about-lyme-disease.pdf

Bob

Good List of Glutathione for PD Studies

I found this while Googling around this evening.

http://www.1whey2health.com/parkinsons_glutathione.htm

Lots of links down at the bottom.

Here is info a blog reader found. She said that www.research1st.com had the original story.

Thanks to Marie for the lead!

PubMed Results

Item 1 of 1

1.	Biomed Pharmacother. 2008 Apr-May;62(4):236-49. Epub 2008 Mar 14. Glutathione and Parkinson's disease: is this the elephant in the room? Zeevalk GD, Razmpour R, Bernard LP. Source University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Department of Neurology, Piscataway, NJ 08854, USA. zeevalgd@umdnj.edu Abstract At least 2 decades have past since the demonstration of a 40-50% deficit in total glutathione (GSH) levels in the substantia nigra in patients with Parkinson's disease (PD). The similar loss of GSH in the nigra in Incidental Lewy body disease, thought to be an early form of PD, indicates that this is one of the earliest derangements to occur in the pre-symptomatic stages of PD. Oxidative damage to lipids, protein and DNA in the nigra of PD patients is consistent with the loss of the antioxidant functions contributed by GSH. Past clinical trials that have used an antioxidant approach to treatment have used antioxidants that might substitute for GSH but these have shown modest to little benefit. More recent studies of the functions served by GSH in cells include in addition to its well-known participation in H(2)O(2) and toxin removal, such roles as modulation of protein function via thiolation which may control physiological and pathophysiological pathways to include DNA synthesis and repair, protein synthesis, amino acid transport, modulation of glutamate receptors and neurohormonal signaling. These multifunctional aspects to the workings of GSH in the cell would suggest that its loss perturbs many different processes and that replenishment and maintenance of GSH per se may be the best approach for preventing progressive damage from occurring. Despite this, few studies have been directed at specifically restoring GSH, although, as discussed herein, its unsanctioned use in PD is growing in popularity. This review will focus on glutathione in PD; the various functions carried out by glutathione and possible consequences of its depletion, as well as measures to elevate GSH in the CNS and its use in humans. Consideration of how the CNS generates and handles the substrates for GSH synthesis is also addressed with the view in mind that this may provide insights into control and maintenance of intracellular glutathione.
	PMID: 18400456 [PubMed - indexed for MEDLINE]

Dr. Joe Burrascano Audio Podcast

Check out this free podcast on iTunes. This is a very candid talk by Joe to an audience of MD's. I found it fascinating and learned a few new things. Presented at the American College for the Advancement of Medicine (ACAM). Thanks to Hootan for the tip.

http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?i=95954705&id=351890855

FDA Alert - Diflucan (fluconazole) - Long-term, High-dose Use During Pregnancy May Be Associated With Birth Defects

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FDA MedWatch Alert Sent to subscribers of: fluconazole systemic Drug Safety Communication: Diflucan (fluconazole) - Long-term, High-dose Use During Pregnancy May Be Associated With Birth Defects August 3, 2011 Audience: OBGYN, Pharmacy, Infectious Disease. ISSUE: FDA is informing the public that treatment with chronic, high doses (400-800mg/day) of Diflucan (fluconazole) during the first trimester of pregnancy may be associated with a rare and distinct set of birth defects in infants. This risk does not appear to be associated with a single, low dose of fluconazole 150mg to treat vaginal yeast infection (candidiasis). Based on this information, the pregnancy category for fluconazole indications (other than vaginal candidiasis) has been changed from category C to category D. The pregnancy category for a single, low dose of fluconazole has not changed and remains category C. Read more... Get these updates via twitter

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Flagyl vs. Tindamax - Bioavailability

I started IV Flagyl today and was researching doses, recommended flow rates, etc. Here's interesting study I just found on the Web. The study compares serum levels of each of these two anti-protozoal drugs over 48-hrs after IV, oral, anal, and vaginal administration. The upshot is that, at least via IV and oral administration, Tindamax has a significantly longer half life.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC184797/pdf/aac00206-0093.pdf

Bob

Fasudil as a Potential Disease Modifying Treatment for Parkinson's

The Michael J. Fox Foundation - Van Andel Research Institute Testing Fasudil as a Potential Disease Modifying Treatment for Parkinson's

13 Most Difficult Diseases to Diagnose

A reader sent this in today. A bit spammy because the blog is about insurance, but the info about the diseases is useful.

Hi Bob,

We would love to share with you an article that we just posted on our own blog! "13 Most Difficult Diseases to Diagnose" is linked below and could be a fun way to share this announcement with your readers.

 (http://www.insurancequotes.org/13-most-difficult-diseases-to-diagnose/)

 It has been a sincere pleasure to read your great content.

Sincerely,

Liz Nutt