What ticks do under your skin: two-photon intravital
imaging of ixodes scapularis feeding in the presence of the
lyme disease spirochete.
Bockenstedt LK, Gonzalez D, Mao J, Li M, Belperron AA,
Haberman A.
/Yale Journal of Biology and Medicine/, 2014 Mar
5;87(1):3-13. eCollection 2014.
Abstract
Lyme disease, due to infection with the Ixodes-tick
transmitted spirochete /Borrelia burgdorferi/, is the most
common tick-transmitted disease in the northern hemisphere.
Our understanding of the tick-pathogen-vertebrate host
interactions that sustain an enzootic cycle for /B.
burgdorferi/ is incomplete.
In this article, we describe a method for imaging the
feeding of /Ixodes scapularis/ nymphs in real-time using
two-photon intravital microscopy and show how this
technology can be applied to view the response of Lyme
borrelia in the skin of an infected host to tick feeding.
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