This is the first study I have bumped into that draws a correlation between unhealthy gut ecology and Parkinson's disease. Considering the state of my gut due to ingestion of antibiotics for Lyme treatment over the years, I wouldn't be surprised if there is a cause and effect relationship between the two. One of my Lyme doctors just ordered a new stool sample for testing the health of my gut. This will use a different lab than the test I had done a month or so ago. The last one used DiagnosTechs. This time we are using Genova lab. I will report the results when I receive them.
I left some links down below that are relevant as well. They were attached to the original abstract so I left them in.
Abstract
Parkinson's disease is associated with gastrointestinal motility abnormalities favoring the occurrence of local infections. The aim of this study was to investigate whether small intestinal bacterial overgrowth contributes to the pathophysiology of motor fluctuations. Thirty-three patients and 30 controls underwent glucose, lactulose, and urea breath tests to detect small intestinal bacterial overgrowth and Helicobacter pylori infection. Patients also underwent ultrasonography to evaluate gastric emptying. The clinical status and plasma concentration of levodopa were assessed after an acute drug challenge with a standard dose of levodopa, and motor complications were assessed by Unified Parkinson's Disease Rating Scale-IV and by 1-week diaries of motor conditions. Patients with small intestinal bacterial overgrowth were treated with rifaximin and were clinically and instrumentally reevaluated 1 and 6 months later. The prevalence of small intestinal bacterial overgrowth was significantly higher in patients than in controls (54.5% vs. 20.0%; P = .01), whereas the prevalence of Helicobacter pylori infection was not (33.3% vs. 26.7%). Compared with patients without any infection, the prevalence of unpredictable fluctuations was significantly higher in patients with both infections (8.3% vs. 87.5%; P = .008). Gastric half-emptying time was significantly longer in patients than in healthy controls but did not differ in patients based on their infective status. Compared with patients without isolated small intestinal bacterial overgrowth, patients with isolated small intestinal bacterial overgrowth had longer off time daily and more episodes of delayed-on and no-on. The eradication of small intestinal bacterial overgrowth resulted in improvement in motor fluctuations without affecting the pharmacokinetics of levodopa. The relapse rate of small intestinal bacterial overgrowth at 6 months was 43%. © 2013 Movement Disorder Society.
Copyright © 2013 Movement Disorder Society.Related Citations
Show allRelated Citations (100)
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- The role of small intestinal bacterial overgrowth in Parkinson's disease.Fasano A, et al. Mov Disord. 2013
- Helicobacter pylori infection and motor fluctuations in patients with Parkinson's disease.Lee WY, et al. Mov Disord. 2008
- Helicobacter pylori eradication for Parkinson's disease.Rees K, et al. Cochrane Database Syst Rev. 2011
- Abnormal breath tests to lactose, fructose and sorbitol in irritable bowel syndrome may be explained by small intestinal bacterial overgrowth.Nucera G, et al. Aliment Pharmacol Ther. 2005
- The long-acting dopamine receptor agonist cabergoline in early Parkinson's disease: final results of a 5-year, double-blind, levodopa-controlled study.Bracco F, et al. CNS Drugs. 2004
- Increased accuracy of the carbon-14 D-xylose breath test in detecting small-intestinal bacterial overgrowth by correction with the gastric emptying rate.Chang CS, et al. Eur J Nucl Med. 1995
- Eradication of small intestinal bacterial overgrowth and oro-cecal transit in diabetics.Cuoco L, et al. Hepatogastroenterology. 2002
- Hydrogen glucose breath test to detect small intestinal bacterial overgrowth: a prevalence case-control study in irritable bowel syndrome.Lupascu A, et al. Aliment Pharmacol Ther. 2005
- Chronic diarrhoea and diabetes mellitus: prevalence of small intestinal bacterial overgrowth.Virally-Monod M, et al. Diabetes Metab. 1998
- Is there a difference in gastric emptying between Parkinson's disease patients under long-term L-dopa therapy with and without motor fluctuations? An analysis using the 13C-acetate breath test.Tanaka Y, et al. J Neurol. 2009
This is the first study I have bumped into that draws a correlation between unhealthy gut ecology and Parkinson's disease. Considering the state of my gut due to ingestion of antibiotics for Lyme treatment over the years, I wouldn't be surprised if there is a cause and effect relationship between the two. One of my Lyme doctors just ordered a new stool sample for testing the health of my gut. This will use a different lab than the test I had done a month or so ago. The last one used DiagnosTechs. This time we are using Genova lab. I will report the results when I receive them.
I left some links down below that are relevant as well. They were attached to the original abstract so I left them in.
Abstract
Parkinson's disease is associated with gastrointestinal motility abnormalities favoring the occurrence of local infections. The aim of this study was to investigate whether small intestinal bacterial overgrowth contributes to the pathophysiology of motor fluctuations. Thirty-three patients and 30 controls underwent glucose, lactulose, and urea breath tests to detect small intestinal bacterial overgrowth and Helicobacter pylori infection. Patients also underwent ultrasonography to evaluate gastric emptying. The clinical status and plasma concentration of levodopa were assessed after an acute drug challenge with a standard dose of levodopa, and motor complications were assessed by Unified Parkinson's Disease Rating Scale-IV and by 1-week diaries of motor conditions. Patients with small intestinal bacterial overgrowth were treated with rifaximin and were clinically and instrumentally reevaluated 1 and 6 months later. The prevalence of small intestinal bacterial overgrowth was significantly higher in patients than in controls (54.5% vs. 20.0%; P = .01), whereas the prevalence of Helicobacter pylori infection was not (33.3% vs. 26.7%). Compared with patients without any infection, the prevalence of unpredictable fluctuations was significantly higher in patients with both infections (8.3% vs. 87.5%; P = .008). Gastric half-emptying time was significantly longer in patients than in healthy controls but did not differ in patients based on their infective status. Compared with patients without isolated small intestinal bacterial overgrowth, patients with isolated small intestinal bacterial overgrowth had longer off time daily and more episodes of delayed-on and no-on. The eradication of small intestinal bacterial overgrowth resulted in improvement in motor fluctuations without affecting the pharmacokinetics of levodopa. The relapse rate of small intestinal bacterial overgrowth at 6 months was 43%. © 2013 Movement Disorder Society.
Copyright © 2013 Movement Disorder Society.Related Citations
Show allRelated Citations (100)
Filter by Free Full Text or Review
- The role of small intestinal bacterial overgrowth in Parkinson's disease.Fasano A, et al. Mov Disord. 2013
- Helicobacter pylori infection and motor fluctuations in patients with Parkinson's disease.Lee WY, et al. Mov Disord. 2008
- Helicobacter pylori eradication for Parkinson's disease.Rees K, et al. Cochrane Database Syst Rev. 2011
- Abnormal breath tests to lactose, fructose and sorbitol in irritable bowel syndrome may be explained by small intestinal bacterial overgrowth.Nucera G, et al. Aliment Pharmacol Ther. 2005
- The long-acting dopamine receptor agonist cabergoline in early Parkinson's disease: final results of a 5-year, double-blind, levodopa-controlled study.Bracco F, et al. CNS Drugs. 2004
- Increased accuracy of the carbon-14 D-xylose breath test in detecting small-intestinal bacterial overgrowth by correction with the gastric emptying rate.Chang CS, et al. Eur J Nucl Med. 1995
- Eradication of small intestinal bacterial overgrowth and oro-cecal transit in diabetics.Cuoco L, et al. Hepatogastroenterology. 2002
- Hydrogen glucose breath test to detect small intestinal bacterial overgrowth: a prevalence case-control study in irritable bowel syndrome.Lupascu A, et al. Aliment Pharmacol Ther. 2005
- Chronic diarrhoea and diabetes mellitus: prevalence of small intestinal bacterial overgrowth.Virally-Monod M, et al. Diabetes Metab. 1998
- Is there a difference in gastric emptying between Parkinson's disease patients under long-term L-dopa therapy with and without motor fluctuations? An analysis using the 13C-acetate breath test.Tanaka Y, et al. J Neurol. 2009
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