Borrelia burgdorferi has been shown to be able to persist in the body. Prior work on Stevia had shown it to be effective against Borrelia biofilms, and in this paper by researchers at the University of New Haven, Stevia was shown to be effective against different morphological forms, as per the three-antibiotic combination (doxy, cefoperazone and daptomycin) shown to be effective by Johns Hopkins researchers. "J. Feng et al.also showed that the three-antibiotic combination (doxycycline, cefoperazone, and daptomycin) was very potent in eliminating the stationary phase rich persisters of Borrelia. In this study, we provided evidence that Stevia A, as an individual agent, was capable of eliminating the spirochetes and the persisters of Borrelia similar to the reported three-drug combination treatment. Our data also showed that the antibiotics in combination on the persisters of Borrelia was indeed consistent with the previous study".
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